This study aims to evaluate the utility of urine reagent strips for bedside cerebrospinal fluid (CSF) analysis, comparing their accuracy with traditional laboratory measurements. In settings where access to advanced laboratory facilities is limited, rapid and reliable diagnostic tools are crucial. The study, conducted over a two-year period at AVBRH hospital in Maharashtra, focuses on neonatology and paediatrics patients undergoing CSF examination. The primary objective is to assess the accuracy of urine reagent strips in semi-quantitative analysis of CSF protein, glucose, and leukocyte esterase. Secondary objectives involve comparing strip values with laboratory measurements, studying the accuracy for different cutoff values, and determining the sensitivity and specificity for CSF protein, sugar, and cells. A sample size of 125 patients was calculated based on the sensitivity and specificity of the reagent strip method, considering a prevalence of meningitis, precision, and a confidence level of 95%. Ethical approval has been obtained, and the study will include patients diagnosed with CNS infection. The methodology encompasses CSF microscopy, biochemical analysis, and urine reagent strip tests. Statistical analyses will employ diagnostic accuracy measures and construct receiver operating curves to determine optimal cutoff levels. This study holds promise for providing a rapid and feasible approach to CSF analysis in resource-constrained healthcare settings.