It has long been assumed that permanent teeth with "irreversible pulpitis" have dental pulp that has been irreparably injured, is beyond repair, and requires root canal therapy.¹The tooth’s survival time is dramatically shortened by this operation. Attempts have been made to use pulpotomy as a therapy strategy in permanent teeth with complete root development presenting symptoms of irreversible pulpitis, where radicular pulp is still healthy, in recognition of the intrinsic healing capacity of an infection-free pulp. The essential pulp should be preserved because it is crucial for induction, formation, nutrition, defence, and sensation in addition to other functions.

In order to treat teeth with pulpitis, pulpotomy, a minimally invasive and biologically based technique, has come back into use. It entails the removal of the coronal portion of the vital pulp in order to preserve the vitality of the remaining radicular region. Devitalization, preservation, and regeneration are the three categories under which pulpotomy can be categorized according to therapeutic goals. There has been a significant increase in interest in regenerative endodontics with the development of mineral trioxide aggregate (MTA).Current innovations include regeneration materials that are antimicrobial, biocompatible, and bioinductive that have been known to stimulate pulp cell regeneration, redirect the inflammatory response, and improve the healing capacity of the remaining healthy vital pulp. MTA is regarded as one of the most widely utilized calcium silicate cements used for this purpose on the basis of evidence demonstrating successful clinical outcomes.It has many benefits over other traditional endodontic materials, such as superior sealing ability, biocompatibility and the capacity to construct a dentin bridge in pulp capping and pulpotomy situations. 

Amelogenins, a class of proteins known to stimulate the growth and proliferation of periodontal ligament cells (PDL), are a major component of another regenerative material, enamel matrix derivative (EMD, Emdogain®), which has been supported for the regeneration of dental tissues. 

Human Biological Membrane is a novel material with substantial stem cell reserves, and they are now gaining prominence among regenerative materials. Its growth factors replicate the stem cell niche for ex vivo growth and offer a natural healing environment. Its natural characteristics include low immunological response, low toxicity, and the capacity to encourage cellular proliferation and attachment. In an era of minimally invasive dentistry, pulpotomy is now increasingly being considered for the management of teeth with irreversible pulpitis and is now being reinvestigated as a definitive treatment option for mature permanent teeth presented with irreversible pulpitis. Therefore, the focused question for this study is: Does using MTA, EMD and Human derived biological membrane in pulpotomy result in better clinical & radiographic outcomes.

Aims and OBJECTIVES

To compare and evaluate the use of MTA, Emdogain and Human biological membrane as pulpotomy agents in permanent teeth with irreversible pulpitis

MATERIAL AND METHODS:

The present study will be conducted in the Department of Conservative Dentistry and Endodontics, Faculty of Dental Science, king George’s medical University, lucknow.

Patient of age group 15 to 45 years with cariously exposed mature permanent teeth will be randomly allocated into 3 groups. Interventional pulpotomy using MTA, EMDOGAIN & HUMAN BIOLOGICAL MEMBRANE will be done in GRP1, 2 & 3 respectively. Clinical and radiographic evaluation will be done at 1 month, 3 months and 6 months.

Data obtained will be statistically analyzed. Any changes deemed in the interest of the study will

be done accordingly.