It is a prospective, observational, open label patient outcome study for patients suffering from Musculoskeletal Disorders entitled “Assessment of likelihood ratio of four characteristic Symptoms of Rhus toxicodendron of Musculoskeletal Disorders (MSD)”. The reliability of homeopathic prescriptions may increase through resource to characteristic signs and symptoms with significant positive likelihood ratio (LR)  results may increase the reliability of homeopathic prescriptions. In this study we will estimate the LR for four characteristic symptoms of Rhus toxicodendron which will attribute to the homeopathic medicine Rhus tox in treatment for MSD. It is multi-centric observational assessment, will be conducted at Dr Anjali Chatterji Regional Research Institute (H), Kolkata , DDPR Central Research Institute (H), Noida and Regional Research Institute (H), Siliguri. All participants in the age group of 18 to 70 years having symptoms of any MSD will be studied. Here, LR will be assessed based on Bayesian statistics of four characteristic symptoms of Rhus toxicodendron in treatment for MSD. Here we will investigate the prevalence of four symptoms (i.e. Ailments from strains/over lifting/overstretching and over exertion 2. Pain < first movement > motion 3. Pain from warm application. 4. Great apprehension at night, cannot remain in bed) in the general patient population (all MSD) and among good responders to Rhus tox in daily homeopathic treatment and estimate LR for these four symptoms of Rhus tox. Rhus tox and Individualized Homoeopathic medicine in centesimal potencies manufactured by a licensed homoeopathic pharmaceutical company approved by the Council.