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CTRI Number  CTRI/2024/01/062169 [Registered on: 31/01/2024] Trial Registered Prospectively
Last Modified On: 06/10/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Homeopathy 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Role of Homoeopathic medicines in the treatment of fever 
Scientific Title of Study   A Randomized Clinical Trial to evaluate the effectiveness of Millesimal and Centesimal Potencies of Homoeopathic Medicines in the management of Pyrexia in Adults Using FAST Tool 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Jeswin Abraham 
Designation  PG scholar 
Affiliation  Vinayaka Missions Homoeopathic Medical College and Hospital 
Address  Department of Organon of Medicine Opd Room no 2e1 Vinayaka Missions Homoeopathic Medical College and Hospital NH47 Sankari Main road Seeragapadi Salem

Salem
TAMIL NADU
636308
India 
Phone  9895119121  
Fax    
Email  jeswinabrahamv9@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Santi Dheepan 
Designation  Assistant professor 
Affiliation  Vinayaka Missions Homoeopathic Medical College and Hospital 
Address  Department of Organon of Medicine Opd Room no 2e1 Vinayaka Missions Homoeopathic Medical College and Hospital NH47 Sankari Main road Seeragapadi Salem

Salem
TAMIL NADU
636308
India 
Phone  9986076195  
Fax    
Email  santiagobear93@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Santi Dheepan 
Designation  Assistant professor 
Affiliation  Vinayaka Missions Homoeopathic Medical College and Hospital 
Address  Department of Organon of Medicine Opd Room no 2e1 Vinayaka Missions Homoeopathic Medical College and Hospital NH47 Sankari Main road Seeragapadi Salem

Salem
TAMIL NADU
636308
India 
Phone  9986076195  
Fax    
Email  santiagobear93@gmail.com  
 
Source of Monetary or Material Support  
Vinayaka Mission Homoeopathic Medical College and Hospital NH47 Sankari Main road Seeragapadi Salem Tamilnadu  
 
Primary Sponsor  
Name  Vinayaka Missions Homoeopathic Medical College and Hospital  
Address  NH47 Sankari Main road Seeragapadi Salem Tamilnadu 636308 India 
Type of Sponsor  Private medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Jeswin Abraham  Vinayaka Missions Homoeopathic Medical College and Hospital  Department of Organon of Medicine Opd Room no 2e1 Vinayaka Missions HomoeopathiC Medical College and Hospital NH47 Sankari Main road Seeragapadi Salem
Salem
TAMIL NADU 
9895119121

jeswinabrahamv9@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethical Committee Vinayaka Missions Kirupananda Variyar Medical College and Hospital Salem  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: R509||Fever, unspecified,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Centesimal potency Homoeopathic medicine  Required Homoeopathic medicine in centesimal potency is selected based on the symptom similarity and administered in water dose (1 drop of medicine is dissolved in 20 teaspoon (100 ml) full of distilled water). The medicine is administered 1 teaspoon (5ml) of medicated solution orally every half hour till betterment occurs. The temperature is monitored every one hour till fever subsides. After administration of medicine the patient is kept under admission in IPD or under observation for about four hours. 
Comparator Agent  Millesimal potency Homoeopathic medicine  Required Homoeopathic medicine in millesimal potency is selected based on the symptom similarity and administered in water dose (1 pill of medicine is dissolved in 20 teaspoon full of distilled water). The medicine is administered 1 tsp of medicated solution orally every half hour till betterment occurs. The temperature is monitored every one hour till fever subsides. After administration of medicine the patient is kept under admission in IPD or under observation for about four hours. 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  1.Patients of age group between 18 – 60 yrs.
2.Both sexes
3.Diagnostic criteria are mainly based on the clinical presentation. 
 
ExclusionCriteria 
Details  1.Patients below 18 yrs. 
2.Adults above 60 yrs.
3.Temperature above 102.2 °F
4.Patients who reported after twenty four hours of onset.
5.Patients who have taken medications other than Homoeopathic prescription for the same.
6.Patients who are suffering from life-threatening diseases, advanced stages of long-standing diseases.
7.Patients who are immune-compromised .
8.Patients who fails to get betterment of temperature parameters within maximum of two hour after administration of first dose. 
 
Method of Generating Random Sequence   Other 
Method of Concealment   Other 
Blinding/Masking   Participant Blinded 
Primary Outcome  
Outcome  TimePoints 
To evaluate the degree of fever reduction by fifty millesimal potency and centesimal potency .  One year and three months 
 
Secondary Outcome  
Outcome  TimePoints 
To compare the efficacy of fever reduction in millesimal and centesimal potencies.  one year three and months 
To assess patient satisfaction and comfort using FAST tool.  one year and three months 
To evaluate the speed of recovery in both of the potency scales using FAST tool.  one year and three months 
To gauge the ease of administration for healthcare professionals.  one year and three months 
 
Target Sample Size   Total Sample Size="60"
Sample Size from India="60" 
Final Enrollment numbers achieved (Total)= "0"
Final Enrollment numbers achieved (India)="0" 
Phase of Trial   Phase 4 
Date of First Enrollment (India)   01/03/2024 
Date of Study Completion (India) Date Missing 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Date Missing 
Estimated Duration of Trial   Years="1"
Months="3"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  
Not Applicable 
Recruitment Status of Trial (India)  Completed 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

In Homoeopathy, acute diseases are classified into epidemic outbreaks, sporadic instances, and uniquely individual cases. The ideal Homoeopathic treatment hinges on a comprehensive understanding of the characteristic symptoms presented by the patient. This is complemented by identifying the root cause of the disease’s exciting factor. Any changes or deviations in the patient’s overall health, often termed ‘altered generals’, are also given prime consideration.

However, certain aspects remain debated even within the well-defined boundaries of Homoeopathic practice. One such aspect is selection of required potency. Finding the right balance and determining the most effective dose is crucial, especially when the stakes are as high as they are with fever management. 

The scales used for prescription are decimal, centesimal and millesimal. Among these decimal and centesimal potencies are widely used and well proven. But certain debates are going on the path of millesimal scale. The fifty millesimal scale or the LM scale was introduced in the sixth edition of Organon of medicine in the year 1921 mainly for the reason that remedies may  be required to be repeated. In order to decrease the drug quantity in the dose and to minimalise aggravation even during the management of chronic diseases, this particular scale was introduced. 

 The primary reason for the different opinions is that the concept was published after the death of master Hahnemann.  As a result many of the practitioners are reluctant in accepting the scale. As a result worldwide research for validating the utility and the scope of this scale is not done extensively when comparing with the other two scales. 

This research seeks to navigate this complex terrain. The primary objective is to analyse the efficiency of fifty millesimal potency and centesimal potency in fever management within the homoeopathic context. Also the speed of recovery in both of the scales is evaluated and compared. By shedding light on this subject, the study aims to clarify and chart a more straightforward path for practitioners in the area of management of acute pyrexia. 

The Organon of Medicine provides a comprehensive account of treating acute diseases using homoeopathic medicines. The Central Council for Research in Homeopathy (CCRH) has actively explored the efficacy of Homoeopathy in managing acute diseases, leading to the publication of numerous articles. Notably, the CCRH Best Dissertation Awards recognize outstanding studies on homoeopathic medicines in the context of acute and chronic diseases. This research also aims to substantiate the effectiveness of homoeopathic medicines, specifically in treating fever.

 
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