Dental implants have revolutionized oral rehabilitation, after 10 years of continuous follow-up, it found that success rate of dental implants is 95%. Osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) are osteoblast-derived factors that compete for binding to the same RANK receptor location and have regulating effects on osteoclastogenesis.   Osteoprotegerin belongs to the tumor necrosis factor receptor superfamily and it encodes for type I transmembrane glycoproteins.  Osteoprotegerin (OPG), also referred to as osteoclast inhibiting factor, is a soluble decoy receptor that can be located in the body. In growing bone, OPG amounts are high and its expression is increased by bone morphogenetic protein (BMP), IL1, TNF, TGF and estrogen. Biochemical changes can be achieved by topically applying biological mediators to the device surface and by applying substances with systemic effects, such as bisphosphonates. (5,6) The term "Vitamin D" applies to a class of vitamin kinds derived from fatty steroid hormones. Ergocalciferol and cholecalciferol are two forms of   Vitamin   D.   Calcitriol, another name for Vitamin D3, is the most active type of Vitamin D and is synthesized when skin cholesterol is exposed to UV radiation. Vitamin D plays a crucial part in maintaining the biological equilibrium of bone and calcium because it directly contributes to calcium absorption in the body. Additionally, this molecule decreases calcium and phosphorus loss while increasing bone reabsorption.  osteoblasts cells contain Vitamin D receptors. The production of genes is also regulated by Vitamin D. The effectiveness of tooth implants is significantly influenced by implant stability. Implant stability can be divided into two categories: biological stability, which results from osseointegration, and mechanical stability, which happens between the implant and bone. Collagen fibers, carbohydrates, cells, and calcium, which comprise the four main components of bone. Remodeling and hardening of bone occur constantly. Remodeling may be mechanical, medical, or biochemical. Following the stretching of the periodontal ligament fibers caused by the application of an orthodontic force, regions of compression and strain form. Osteoblastic activity can be seen in areas of strain while osteoclastic activity can be seen in regions of compression. 

Aim of the study is to Evaluation of salivary Osteoprotegerin (OPG) through UV irradiated topical application of Vitamin D on implant surface during placement.