A total of 50 patients presenting to the Department of Dermatology, Eras Lucknow Medical College and Hospital, Lucknow of stable vitiligo i.e. Lack of progression of old lesions within the past 6 months and No new lesions developing within the same period will be approached for participation in the study. Patients meeting the inclusion and exclusion criteria and giving written consent for participating in the study shall be recruited. History and clinical examination with photographic documentation, and VASI (Vitiligo Area Severity Index) score will be done before starting treatment and then at each visit. Patients will be randomly divided into two groups – A and B each containing 25 individuals. In group A – Patients will be advised to apply Bimatoprost (0.03%) ophthalmic solution twice daily over the lesion for 12 weeks. In group B – Patients will be advised to apply tacrolimus (0.1%) ointment twice daily over the lesion for 12 weeks. Patients will be followed up at 4, 8, and 12 weeks and at each follow-up visit clinical response will be determined by the reduction in subjective response and VASI score. Based on the reduction in the subjective response and VASI score the therapeutic efficacy is graded.

If at any point, any patient withdraws the consent or started developing new lesions during the study or does not come for 2 consecutive follow-ups despite telephonic reminder. He/She shall be considered dropped out of the study.