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CTRI Number  CTRI/2024/10/074816 [Registered on: 07/10/2024] Trial Registered Prospectively
Last Modified On: 11/09/2025
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Ayurveda 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   Comparisson of Marma stimulation and selected ayurvedic treatments in cervical radiculopathy. 
Scientific Title of Study   A clinical study to evaluate the effect of stimulation of selected Marma points in comparison with rooksha sweda and abhyanga-ushmasweda in the management of pain in cervical radiculopathy. 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Sourav KT 
Designation  PG scholar 
Affiliation  Government ayurveda college, trivandrum, kerala 
Address  Department of shalyatantra,3rd floor, room - sushruta hall, op room 3 Government ayurveda medical college and hospital, NH 66 Vanchiyoor, trivandrum, kerala

Thiruvananthapuram
KERALA
695001
India 
Phone  9995671529  
Fax    
Email  dr.sourav.kt@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  Sourav KT 
Designation  PG scholar 
Affiliation  Government ayurveda college, trivandrum, kerala 
Address  Department of shalyatantra 3rd floor room - sushruta hall, op room 3 Government ayurveda medical college and hospital, NH 66 Vanchiyoor, trivandrum, kerala

Thiruvananthapuram
KERALA
695001
India 
Phone  9995671529  
Fax    
Email  dr.sourav.kt@gmail.com  
 
Details of Contact Person
Public Query  
Name  Dr Remya V R 
Designation  Assistant professor 
Affiliation  Government Ayurveda college Trivandrum 
Address  Department of shalyatantra, 3rd floor room - sushruta hall, op room 3, Government ayurveda medical college and hospital, NH 66 Vanchiyoor, trivandrum, kerala

Thiruvananthapuram
KERALA
695001
India 
Phone  9947035121  
Fax    
Email  remyarenjith3487@gmail.com  
 
Source of Monetary or Material Support  
Government ayurveda college, Thiruvananthapuram 
 
Primary Sponsor  
Name  nil 
Address  nil 
Type of Sponsor  Other [nil] 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Sourav KT  Goverment Ayurveda College, Thiruvananthapuram  Department of shalyatantra, 3rd floor, room - sushruta hall, op room 3 Government Ayurveda Medical College and Hospital, NH66, Vanchiyoor PIN 695001
Thiruvananthapuram
KERALA 		 9995671529

dr.sourav.kt@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional Ethical committee Government Ayurveda college,Trivandrum  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:M501||Cervical disc disorder with radiculopathy. Ayurveda Condition: VISVACI,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmProcedure-marmacikitsA, मर्मचिकित्सा (Procedure Reference: marma therapy, Procedure details: marma point stimulation, total duration 25-30 minutes. procedure performed on every alternative day)
(1) Medicine Name: Dhanwantharam kashaya, Reference: sahasrayogam, Route: Oral, Dosage Form: Kwatha/Kashaya, Dose: 90(ml), Frequency: bd, Duration: 15 Days
(2) Medicine Name: yoga raja guggulu, Reference: bhaishagya ratnavali, Route: Oral, Dosage Form: Gutika/Vati/Ghana Vati/Tablets, Dose: 750(mg), Frequency: bd, Duration: 15 Days
2Comparator ArmProcedure-aBya~ggaH, अभ्यंग  (Procedure Reference: charaka samhita, Procedure details: after 7 days of churna pottali sweda oil massage is done for next 7 days)
(1) Medicine Name: murivenna, Reference: pharmacopia,GAVC,TVM, Route: Topical, Dosage Form: Taila, Dose: 200(ml), Frequency: od, Duration: 7 Days
(2) Medicine Name: dhanwantharam kashayam, Reference: sahasrayogam, Route: Oral, Dosage Form: Kwatha/Kashaya, Dose: 90(ml), Frequency: bd, Duration: 7 Days
(3) Medicine Name: yoga raja guggulu, Reference: bhaishagya ratnavali, Route: Oral, Dosage Form: Gutika/Vati/Ghana Vati/Tablets, Dose: 750(mg), Frequency: bd, Duration: 7 Days
3Comparator ArmProcedure-svedanam, स्वेदनम् (Procedure Reference: charaka samhita, Procedure details: churna pottali sveda)
(1) Medicine Name: kolakulathadi churna, Reference: charaka samhita, Route: Topical, Dosage Form: Churna/ Powder, Dose: 500(g), Frequency: od, Duration: 7 Days
(2) Medicine Name: dhanwantharam kashayam, Reference: sahasrayogam, Route: Oral, Dosage Form: Kwatha/Kashaya, Dose: 90(ml), Frequency: bd, Duration: 7 Days
(3) Medicine Name: yoga raja guggulu, Reference: bhaishagya ratnavali, Route: Oral, Dosage Form: Gutika/Vati/Ghana Vati/Tablets, Dose: 750(mg), Frequency: bd, Duration: 7 Days
4Comparator ArmProcedure-virecana-karma, विरेचन-कर्म (Procedure Reference: charak samhita, Procedure details: after 7 days of churna pottali sveda & 7 days of abhyanga virechana as a mild purgation is done on the 15th day)
(1) Medicine Name: gandharvahastadi eranda tailam, Reference: ashtanga hrudayam, Route: Oral, Dosage Form: Taila, Dose: 10(ml), Frequency: od, Duration: 1 Days
 
Inclusion Criteria  
Age From  20.00 Year(s)
Age To  60.00 Year(s)
Gender  Both 
Details  Participants with clinically diagnosed Cervical radiculopathy 
 
ExclusionCriteria 
Details  Acute trauma to cervcal spine, fracture of cervical spine, cervical rib, congenital abnormalities in the cervical region, known case of monoplegia, hemiplegia, paraplegia, quadriplegia, participants with uncontrolled diabetes mellitus and hypertension, pregnant and lactating women. 
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Case Record Numbers 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
pain  0th day before and after treatment, 7th day,15th day 
 
Secondary Outcome  
Outcome  TimePoints 
Motor strength  0th day before and after treatment, 7th day,15th day 
Sensation of Dermatomes  0th day before and after treatment, 7th day,15th day 
Triceps tendon reflex  0th day before and after treatment, 7th day,15th day 
Spurling test  0th day before and after treatment, 7th day,15th day 
Bakody sign  0th day before and after treatment, 7th day,15th day 
 
Target Sample Size   Total Sample Size="30"
Sample Size from India="30" 
Final Enrollment numbers achieved (Total)= "30"
Final Enrollment numbers achieved (India)="30" 
Phase of Trial   Phase 2 
Date of First Enrollment (India)   01/11/2024 
Date of Study Completion (India) 22/09/2025 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) 22/09/2025 
Estimated Duration of Trial   Years="1"
Months="0"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  		 Not Applicable 
Recruitment Status of Trial (India)  Completed 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

Cervical radiculopathy is a neurological condition affecting the cervical nerve roots due to intervertebral disc herniations or degenerative changes of the neural foramen. It is characterised by pain in the neck radiating to the upper limb, motor dysfunction and numbness. Diminished triceps tendon reflex occurs in more than half of the cases. Cervical radiculopathy is having a prevalence of 3.5 cases per 1000 population.

            Viswachi is a vatavyadhi characterised by features like ‘bahu chesta apaharini’ or ‘bahu karma kshayakari’ due to affliction of ‘kandara’ of upper limb by vata. Considering the etiopathogenesis and clinical features, viswachi can be corelated to cervical radiculopathy.

            Ayurveda classic have explained 107 vital points in the human body termed as marma. They are defined as the confluence of mamsa, sira, snayu, asthi and sandhi7 and as the sites where prana resides. The traditional practice of marma explor 
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