Gallstones are the most prevalent issue affecting the biliary system. They impact around 10-15% of the world population, approximately 4% in India with over 80% of those affected experiencing symptoms at some point in their lives, and 1-2% requiring surgery annually. Among them males affected are 6.2% and females are at 7.3%. Asymptomatic gallstones will be monitored, while surgery (cholecystectomy) is reserved for symptomatic cases or those with complications.

               Ashmari (caliculi) in Ayurveda mainly focuses on urinary stones with the classification of Dosha predominancy. Pittaja Ashmari pathogenesis can be considered here. Ashmari Bhedana Dravyas (Litholytic and Lithotripsic drugs) have been explained in many Samhitas, Nighantus and Rasa Granthas. Considering the risk of complications by cholelithiasis, limited medical managements available in contemporary systems, necessity for evaluating, updating and validating the ayurvedic treatments; there is a high need for the present clinical study to evaluate the efficacy of Patolamuladi Kwatha followed by Navasadara and Badarashma in the Management of Cholelithiasis. The scientific research for the authentication of these easily available, cost effective and unique combination is highly needed.