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CTRI Number  CTRI/2023/12/060526 [Registered on: 19/12/2023] Trial Registered Prospectively
Last Modified On: 18/09/2026
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda 
Study Design  Randomized, Parallel Group Trial 
Public Title of Study   Placement of local drug delivery Liquorice gel in subgingival pockets in chronic periodontitis patients 
Scientific Title of Study   Evaluation of the efficacy of Liquorice gel as an adjunct to non-surgical periodontal therapy in chronic periodontitis:A randomized control, clinico-microbial trial. 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Vaishnavi Sanjay Shah 
Designation  Post-graduate student 
Affiliation  Yogita Dental College and Hospital , Khed 
Address  Yogita Dental College and Hospital , Khed, Ratnagiri, Department of Periodontology(24)

Ratnagiri
MAHARASHTRA
415709
India 
Phone  9730120332  
Fax    
Email  drshahvaishnavi123@gmail.com  
 
Details of Contact Person
Scientific Query  
Name  DrPrashanth Shetty 
Designation  Professor 
Affiliation  Yogita Dental College and Hospital , Khed 
Address  Yogita Dental College and Hospital , Khed, Ratnagiri, Department of Periodontology(24)

Ratnagiri
MAHARASHTRA
415709
India 
Phone  9886191999  
Fax    
Email  drprashanthshetty3@gmail.com  
 
Details of Contact Person
Public Query  
Name  DrPrashanth Shetty 
Designation  Professor 
Affiliation  Yogita Dental College and Hospital , Khed 
Address  Yogita dental college and hospital , Khed , Ratnagiri, Department of Periodontology (24)

Ratnagiri
MAHARASHTRA
415709
India 
Phone  9886191999  
Fax    
Email  drprashanthshetty3@gmail.com  
 
Source of Monetary or Material Support  
Yogita Dental College and Hospital , Khed , Ratnagiri, Department of Periodontology (24) 
 
Primary Sponsor  
Name  Dr Vaishnavi Shah 
Address  yogita dental college and hospital, khed , ratnagiri 
Type of Sponsor  Research institution 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Vaishnavi Shah  Yogita Dental College and Hospital  Yogita Dental College and Hospital, Khed , Ratnagiri, Department of Periodontology (24)
Ratnagiri
MAHARASHTRA 		 9730120332

drshahvaishnavi123@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
YOGITA DENTAL COLLEGE INSTITUTIONAL ETHICAL COMMITTE  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: K053||Chronic periodontitis,  
 
Intervention / Comparator Agent  
Type  Name  Details 
Intervention  Liquorice gel  The study spans for 3months in which the the intervention agent Liquorice gel application will be done only once after scaling and root planing in the whole study span. 
Comparator Agent  Scaling and root planing  The study span for 3 months in which the standard protocol for periodontitis patients that is scaling and root planing will be done at baseline . 
 
Inclusion Criteria  
Age From  18.00 Year(s)
Age To  50.00 Year(s)
Gender  Both 
Details  1.A minimum of 20 natural teeth present
3.Healthy patients diagnosed with chronic periodontitis.
4. Patients having pocket probing depth of 4-6 mm.
 
 
ExclusionCriteria 
Details  1.Tobacco-smokers, electronic cigarette users, smokeless tobacco product users, alcohol users.
2.Individuals that had used antibiotics, probiotics, non-steroidal anti-inflammatory drugs and/or steroids within the past 3-month.
3.Individuals with systemic diseases (such as cardiovascular diseases,diabetes,, renal disorders, hepatic disorders and/or acquired immune deficiency syndrome/HIV.)
4.Lactating and/or pregnant females.
5.Third molars and fractured teeth with embedded root remnants.
6.Completely edentulous individuals.
 
 
Method of Generating Random Sequence   Coin toss, Lottery, toss of dice, shuffling cards etc 
Method of Concealment   Not Applicable 
Blinding/Masking   Participant and Outcome Assessor Blinded 
Primary Outcome  
Outcome  TimePoints 
Clinical attachment loss, Probing Depth, Microbial count  Baseline , 1 month , 3 month 
 
Secondary Outcome  
Outcome  TimePoints 
Plaque index , Sulcus Bleeding Index  Baseline , 1 month , 3 month 
 
Target Sample Size   Total Sample Size="30"
Sample Size from India="30" 
Final Enrollment numbers achieved (Total)= "30"
Final Enrollment numbers achieved (India)="30" 
Phase of Trial   Phase 3/ Phase 4 
Date of First Enrollment (India)   02/01/2024 
Date of Study Completion (India) 20/03/2024 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Date Missing 
Estimated Duration of Trial   Years="1"
Months="6"
Days="30" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Completed 
Publication Details
Modification(s)  		 Shah, V., Shetty, P., Shetty, D. et al. Effectiveness of liquorice gel as an adjunct to non-surgical periodontal therapy in chronic periodontitis: a randomized controlled, clinical and microbiological trial. Sci Rep 2026.  
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary
Modification(s)  
Dental plaque bacteria are the primary cause of periodontitis, leading to inflammation of periodontal supporting tissues. For non-surgical therapy, scaling and root planing (SRP) is still the best option. Liquorice, a herbal agent rich in bioactive metabolites such as glabridin, glycyrrhizin, licoricidin, licochalcone A, and licorisoflavan A, has shown potential benefits in oral health. However, limited in vivo evidence exists regarding its efficacy in periodontitis. Therefore, this study aimed to evaluate the effectiveness of liquorice gel as an adjunct to SRP in patients with periodontitis. A randomized controlled clinical trial (RCT) was conducted involving 32 adults with moderate pockets and chronic periodontitis, who were randomly allocated to the two groups. Group A (test group, SRP + Liquorice gel), and Group B (control group, SRP). All patients underwent a comprehensive scaling and root planing procedure, received oral hygiene instructions, and were recalled after 21 days (baseline). Patients with persistent pockets were included in the study. Clinical parameters like probing pocket depth (PPD), clinical attachment level (CAL), sulcus bleeding index (SBI), and plaque index (PI), along with microbiological indicators, were assessed at baseline, 1 month, and 3 months. Statistical analysis was performed using Friedman’s test followed by the Mann–Whitney U test for intergroup comparison. Both groups demonstrated significant clinical and microbiological improvements from baseline to 1 month and 3 months (p < 0.001). The test group receiving liquorice gel adjunctive to scaling and root planing demonstrated greater reductions in plaque index (PI) and sulcus bleeding index (SBI), along with comparatively greater suppression of Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Clinical attachment level (CAL) improvements were comparable between groups. Both groups also demonstrated significant reductions in probing pocket depth (PPD) over the study period; however, intergroup differences in PPD were not statistically significant at the evaluated follow up intervals. Adjunctive liquorice gel was associated with additional improvements in selected clinical and microbiological outcomes, particularly plaque accumulation, gingival bleeding, and selected periodontal pathogens, compared with SRP alone over the three-month follow-up period.
 
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