Temporomandibular Disorders (TMD) affect jaw movement, causing pain and discomfort. Treatment often involves occlusal splints, traditionally made with heat-cured acrylic. Advancements in 3-D printing offer new possibilities, but their effectiveness needs evaluation. Current research relies on subjective measures, lacking objective tools like T-Scan and Joint Vibration Analysis. Comparing conventional techniques with 3-D printed splints could provide insights into treatment success. Thus, a thorough assessment is necessary before transitioning to digital workflows in removable prosthetics. The aim of this study was to compare and evaluate the effectiveness of 3D printed occlusal splints to conventional occlusal splints in treating Temporomandibular Joint Disorder, utilizing advanced digital evaluation tools in a human trial. Specifically, the objectives were to compare the performance of 3D printed occlusal splints with conventional ones using advanced digital tools like JVA and T-scan, assess the efficiency of 3D printed occlusal splints in managing TMJ disorders, and measure TMJ pain levels using the visual analogue scale. The study was designed as a blinded crossover randomized controlled trial in accordance with the CONSORT guidelines. Twenty patients requiring occlusal splint therapy were included in the study based on the selected inclusion and exclusion criteria. Patients were divided into two groups. Each group received stabilization occlusal splint, one fabricated using conventional compression molding technique and the other using 3D printing technique with a 2-week follow-up period. The outcome measures were Pain assessment using VAS, occlusal contacts using T-scan, and TMJ health assessment using JVA.