Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder which is characterized by abdominal pain and abnormal defecation patterns. The global prevalence is estimated between 10% and 20%. IBS is classified into four subtypes: IBS with predominant constipation (IBS-C), IBS with predominant diarrhea (IBS-D), with mixed bowel habits (IBS-M) or IBS, unsubtyped. IBS manifests as a collection of gastrointestinal symptoms that change significantly from patient to patient and return on an episodic basis. Abdominal pain or abdominal discomfort with altered bowel habit is the predominant feature of IBS. There may be alternating diarrhea and constipation, and other associated symptoms include mainly gas bloating, which is temporarily relieved by defecation, upper gastrointestinal symptoms like dyspepsia, heartburn etc. Many patients with IBS suffer from visceral hypersensitivity i.e. ‘feel their gut too much’, from anxiety, depressed mood and various symptoms from many other regions of the body (a phenomenon called somatization). This condition is associated with impaired quality of life and limitations in daily activities, without affecting overall survival. The economic burden of the disease is substantial at the individual, healthcare system and societal levels. Severe IBS can significantly alter quality of life,      disrupt daily activities, and result in inflated healthcare costs. As IBS is merely a symptom-based condition so it can be better managed or treated by homoeopathy which is also based upon the principle of symptom similarities. Individualization is the process of arriving at the image of the patient for the selection of remedy. The customary way of individualization of the patient is through the construction of totality of symptoms according to which Similimum is prescribed. Along with constitutional medicines based on individualization there is another group of medicines that have been prepared and proven from the human gut flora named Bowel Nosodes. Since homeopathy’s effectiveness for irritable bowel syndrome has not yet been exhaustively investigated, more studies that adhere to the highest methodological standards are required. In this study we aim to assess the efficacy of individualized homoeopathic medicines or bowel nosodes compared to placebo with regard to disease-specific quality of life in patients with IBS. Along with it symptom severity of IBS, stool consistency and stool culture of patients will be assessed. Dietary modifications will be given in all the three groups.