IDA in SCD is multifactorial resulting from ongoing haemolysis, chronic inflammation and micronutrient deficiency. It is presumed that IDA is uncommon in SCD because of recirculation of iron from ongoing hemolysis and blood transfusions patients receive. Various studies mentioned its significant prevalence from 28-67%. Recent study in SCD-pregnant women from Orrisa revealed high/elevated iron stores in them. Diagnosing IDA in SCD is challenging due to elevated ferritin levels and coinheritance of α-thalassemia causing hypochromic-microcytosis. So, IDA can often go unnoticed/underdiagnosed. Murine models showed iron-restricted diet helped in reducing crisis-episodes with potential benefit in reducing organ damages. Thus, some important clinical questions remain to be answered for optimum management of IDA viz. appropriate diagnosis and role of iron therapy.

Novelty:

1. Exact prevalence of IDA in Indian SCD will be calculated after correct diagnosis.

2. Role of iron therapy will be established as many clinicians avoid it in fear of toxicity.

Objectives:

1. To measure prevalence of IDA in SCD

2. To corelate clinical features and complications in SCD patients with their iron status

3. To understand effect of iron therapy on clinical manifestations and Hb-levels in SCD patients with IDA

Methods:

It will be a prospective study. Using various laboratory investigations correct estimate of IDA in Indian SCD will be calculated and diagnosed patients will be prescribed oral iron therapy and followed up for response.

Expected outcome:

1. Exact prevalence of IDA in Indian SCD will be calculated.

2. Role of various laboratory investigations for correct diagnosis will be proposed.

3. Early diagnosis and interventions will help to combat deleterious complications of anemia.