A) Introduction:

 The purpose of this study is to understand toxicities, prognostic factors, outcomes, and survival rates for the chemotherapy protocol “OGS-12” used in our institute

 The study intends to explore the safety and efficacy of this chemotherapy protocol and additional concerns relevant to adolescents and young adults in whom this tumor is most common, such as fertility and social implications among survivors

 B) Diagnosis, type of cancer

 i) Osteosarcoma is the most common bone tumor in children and young adolescents.

 ii) It is aggressive but sensitive to chemotherapy.

iii) The patients in this study have localized diseases that had not spread to other sites at diagnosis. They have been treated with surgery and chemotherapy to reduce the chance of disease relapse. 

C) Options for investigating, diagnosing, and treating this disease:

i) Osteosarcoma is generally diagnosed using physical examination of the tumor site, radiological tests (magnetic resonance imaging and computed tomography (MRI, CT chest), tissue biopsy (removing tumor cells for testing of cancer), and blood tests.

 ii) The following treatment options are available for your type of breast cancer, Treatment available for your type of cancer: o Standard treatment consists of surgery to remove the tumor (local therapy) and chemotherapy (systemic therapy) to prevent the chances of disease relapse and radiation therapy in some cases (high-powered radiation energy to kill cancer cells). 

D) Possible risks and benefits with the available and proposed treatments:

i) Treatment available for your type of cancer: Standard treatment consists of surgery to remove the tumor (local therapy) and chemotherapy (systemic therapy) to prevent the chances of disease relapse.

ii) Treatment proposed in this study Patients are treated with the standard institutional protocol consisting of surgery to remove the tumor (local therapy) and chemotherapy (systemic therapy) to prevent the chances of disease relapse

E) Where and how the treatment and follow-up  will be done:

 i) Treatment: The treatment is done at Tata Memorial Hospital BST (Bone and Soft Tissue) OPD

 ii) Follow-up: The follow-up is done at Tata Memorial Hospital BST (Bone and Soft Tissue) OPD F) Time and costs involved 

iii) Time: Not applicable as the study details are being collected from electronic medical records

iv) Cost: Not applicable as the study details are being collected from electronic medical records