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CTRI Number  CTRI/2023/10/058786 [Registered on: 18/10/2023] Trial Registered Prospectively
Last Modified On: 24/11/2023
Post Graduate Thesis  No 
Type of Trial  PMS 
Type of Study   Drug 
Study Design  Single Arm Study 
Public Title of Study   To evaluate the safety and efficacy of baby tummy roll on in 0-36 months babies. 
Scientific Title of Study   Post Marketing Observational Study PMOS To Evaluate the Safety and Efficacy of HBTM 102109 Baby Tummy Roll On in 0-36 Months Babies 
Trial Acronym  NIL 
Secondary IDs if Any  
Secondary ID  Identifier 
HWC/MSCD/CPD/012/2023 Version No: 1.0, Dated 19 July 2023  Protocol Number 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Mohit Poddar 
Designation  Consultant 
Affiliation  Poddar Hospital 
Address  Department of Pediatrics, Room No. 1, Ground Floor, 3510AB, Langar Ke Balaji Ka Rasta, Gangori Bazar, Jaipur 302001, Rajasthan

Jaipur
RAJASTHAN
302004
India 
Phone  9829666655  
Fax    
Email  drmohitpoddar@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Soorya Narayan 
Designation  Manager- Clinical Operations - MSCD & RD 
Affiliation  Himalaya Wellness Company 
Address  Room No 301,3rd Floor, Clinical Pharmacology, Research and Development Makali, Tumkur Road, Bangalore Rural, KARNATAKA – 562162, India

Bangalore Rural
KARNATAKA
562162
India 
Phone  918067549919  
Fax    
Email  dr.sooryanarayan.h@himalayawellness.com  
 
Details of Contact Person
Public Query
 
Name  Dr Swathi B  
Designation  Clinical Team Lead - Personal Care - MSCD & RD 
Affiliation  Himalaya Wellness Company 
Address  Room No 301,3rd Floor, Clinical Pharmacology, Research and Development Makali, Tumkur Road, Bangalore Rural, KARNATAKA – 562162, India

Bangalore Rural
KARNATAKA
562162
India 
Phone  918067547232  
Fax    
Email  dr.swathi.b@himalayawellness.com  
 
Source of Monetary or Material Support  
Himalaya Wellness Company NH 4, Makali, Tumkur Road, Makali Aluru Main Road Opposite to JCB Bangalore Rural, Karnataka, 562162 India  
 
Primary Sponsor  
Name  Himalaya Wellness Company 
Address  NH 4, Makali, Tumkur Road, Makali Aluru Main Road Opposite to JCB Bangalore Rural, Karnataka, 562162 India  
Type of Sponsor  Pharmaceutical industry-Indian 
 
Details of Secondary Sponsor  
Name  Address 
JSS Medical Research Asia Pacific Private Limited  Tower 2, 1st Floor, South Wing, L&T Business Park, Plot no 12/4, Sector 27 D, Delhi Mathura Road, Near Sarai Khwaja Metro Station, Faridabad -121003, Haryana, India 
 
Countries of Recruitment     India  
Sites of Study
Modification(s)  
No of Sites = 20  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Mukund Sangamnerkar  Chinmay Nursing Home  Room No. 1, Ground Floor, 210/B, Navi peth Pune-411030, Maharashtra
Pune
MAHARASHTRA 
09822057651

mmsangamnerkar@gmail.com 
Dr Sameer Punia  Cradle Care Clinic  Flat no. 89, Pocket 1, DDA Flats, Sector 9, Dwarka, New Delhi - 110075
New Delhi
DELHI 
9910000561

sameerpunia@gmail.com 
Dr Sunil Agrawal  Cradle Children Hospital  Basement Room No. 2, 212 Nemi Nagar Extension, Vaishali Nagar, Jaipur
Jaipur
RAJASTHAN 
08302222120

cradlehospitalresearch@gmail.com 
Dr Sachin Bhargava  Dr. Bhargava Clinic  Kshitij Complex, Shop No. 10-11, First Floor, Sector -4, VAISHALI, GHAZIABAD. 201010, Uttar Pradesh
Ghaziabad
UTTAR PRADESH 
8800340247

clinicbhargava@gmail.com 
Dr Ashok Bhandari  Dr. M K Shah Medical College and Research Centre and SMS Multispeciality hospital  Pediatric OPD, 1st Floor, Visat Gandhinagar Highway, Near Tapovan Circle, Chandkheda, Ahmedabad - 382424
Gandhinagar
GUJARAT 
09869922323

ashokavitaditi@gmail.com 
Dr Sunil Garg  Garg Child Hospital  Room No. 3, Basement Floor, Dept. of Pediatrics 40, Ajmer Road, Near Sagar Market Bhakrota, Jaipur – 302026
Jaipur
RAJASTHAN 
9983308656

gargchildhospitalresearch@gmail.com 
Dr Umesh Chaudhari  Imperial Multispecialty Hospital  Ground Floor, Department of Pediatrics, Gat No.1193, Pingle Pride, Near Radha Swami Ashram, Chikhali, Pune-411062, Maharashtra, India
Pune
MAHARASHTRA 
9978442085

drumeshchaudhari23@gmail.com 
Dr Karuppiah Pandi A  J Care Women And Child Clinic  No. 1, 4th Street, Kailash Nagar, Lawspet, Puducherry 605008
Pondicherry
PONDICHERRY 
06382833315

ikpandi85@gmail.com 
Dr Preetam Kumar  Kamla Nursing Home  Kamla Nursing Home, Ground Floor, Ramnagar, Varanasi, 221008 Uttar Pradesh
Varanasi
UTTAR PRADESH 
09026660468

preetambhu87@gmail.com 
Dr Vishal Rathod  Little Miracles Children Hospital  5th floor, block B, Department of Pediatrics, Room No. 1, Pramukh Mastana Complex, Reliance cross road, Kudasan, Gandhinagar – 382421
Gandhinagar
GUJARAT 
09978951818

drvishal1712@yahoo.co.in 
Dr Varnit Shankar  Medihub Multispeciality Clinic  Basement Room No. 1, 269, Lane no. 4, Vashishth Marg, Raja Park, Jaipur 302004
Jaipur
RAJASTHAN 
09929779306

medihubjaipur@gmail.com 
Dr Pramod Jog  Medipoint Hospitals Pvt Ltd  Clinic Building, 3rd floor, Department of Pediatrics, 241/1, New D P Road, Aundh Baner Boundary, Baner Road, Pune - 411007, Maharashtra, India
Pune
MAHARASHTRA 
09423309677

drpramod.medipoint@gmail.com 
Dr Prashanth M V  Medstar Specility Hospital  641/17/1/3, 2nd Floor, Kodigehalli Main Road, Sahakarnagar, Bangalore, Karanataka, India 560092
Bangalore
KARNATAKA 
09731748559

drmvprashanth@gmail.com 
Dr Prabhat Kumar  Om Pradyot Clinic  Ground Floor, Rajendra Vihar Colony, Newada, Sunderpur, Varanasi, Uttar Pradesh - 221005
Varanasi
UTTAR PRADESH 
09807636717

dr_prt@yahoo.co.in 
Dr Mohit Poddar  Poddar Hospital  Address: 3510AB, Langar Ke Balaji Ka Rasta, Gangori Bazar, Near Neemdi Police Station, Jaipur 302001
Jaipur
RAJASTHAN 
09829666655

drmohitpoddar@gmail.com 
Dr Avinash Kumar Rai  Rama Child Care  Ground Floor, OPD Room, Saamne Ghat, Lanka, Balaji Nagar, Road, Uttar Pradesh 221005
Varanasi
UTTAR PRADESH 
09140010967

dr.avinashrai@yahoo.in 
Dr Chirag Banker  Shiven Children Hospital  A block 608, 6th Floor, Vrundavan trade centre, Reliance Cross Rd, opp. kanam Farm, Kudasan, Gandhinagar, Gujarat 382421
Gandhinagar
GUJARAT 
9978442085

drchirag2804@yahoo.com 
Dr Rajan Sareen  Shri Krishna Mother and Child Clinic  Ground Floor, L-76/A, Pocket - L, Dilshad Garden, Delhi - 110095
New Delhi
DELHI 
9810543682682

rajansareen77@gmail.com 
Dr Bharath Kumar  Thavanshika Clinic  41, Cuddalore main road, Arriyankuppam, Puducherry 605007
Pondicherry
PONDICHERRY 
09003468873

scooby_25575@yahoo.com 
Dr Chandrakant Sahare  Vishwaraj Hospital  Admin Block, 3rd Floor, Room Number 3, Pune-Solapur Road, Near Loni Railway Station, Kadamvakvasti, Pune - 412201
Pune
MAHARASHTRA 
09158000642

cps11aug@gmail.com 
 
Details of Ethics Committee
Modification(s)  
No of Ethics Committees= 20  
Name of Committee  Approval Status 
Ethique De La Nature Association- J Care Women and Child Clinic  Approved 
Ethique De La Nature Association-Thavanshika Clinic, Puducherry India  Approved 
Genebandhu Independent Ethics Committee- Dr. Bhargava Clinic, VAISHALI, GHAZIABAD. 201010, Uttar Pradesh  Approved 
Genebandhu Independent Ethics Committee-Cradle Care Clinic ,Sector 9, Dwarka, New Delhi – 110075  Approved 
Genebandhu Independent Ethics Committee-Shri Krishna Mother and Child Clinic Dilshad Garden, Delhi - 110095  Approved 
Hi-Tech Multispeciality Hospital-Shiven Children Hospital  Approved 
HiTech Ethics Committee-Dr. M K Shah Medical College and Research Centre and SMS Multispeciality hospital, Ahmedabad Gujrat  Approved 
HiTech Ethics Committee-Little Miracles Children Hospital, Gandhinagar Gujarat  Approved 
Medstar Speciality Hospital Ethics Committee- Medstar Specility Hospital, Bangalore Karnataka  Approved 
P. R. Poddar Institutional Ethics Committee- Garg Child Hospital  Approved 
P. R. Poddar Institutional Ethics Committee-Cradle Children Hospital, Jaipur Rajasthan  Approved 
P. R. Poddar Institutional Ethics Committee-Medihub Multispeciality Clinic, Jaipur Rajasthan  Approved 
P. R. Poddar Institutional Ethics Committee-Poddar Hospital Jaipur 302001, Rajasthan  Approved 
Penta-Med Ethics Committee- Medipoint Hospitals Pvt Ltd, Baner Road, Pune411007, Maharashtra, India.  Approved 
Penta-Med Ethics Committee-Chinmay Nursing Home, Navi peth Pune-411030, Maharashtra  Approved 
Penta-Med Ethics Committee-Imperial Multispecialty Hospital  Approved 
Penta-Med Ethics Committee-Vishwaraj Hospital Pune Maharashtra  Approved 
Yakshit Independent Ethics Committe,Varanasi ,Uttar Pradesh,221001   Approved 
Yakshit Independent Ethics Committee , Varanasi ,Uttar Pradesh ,221001  Approved 
Yakshit Independent Ethics Committee, Varanasi,Uttar Pradesh,221001  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition: K928||Other specified diseases of the digestive system,  
 
Intervention / Comparator Agent
Modification(s)  
Type  Name  Details 
Intervention  Baby tummy roll on  Baby Tummy Roll on is a pure, natural formula that soothes and relaxes babys tummy. This comforting oil is formulated with the gentlest hing oil, saunf oil and calming natural essential oils of Chamomile, Frankincense and Cardamom. Massage has many benefits for the baby, provide calms, comforts on baby’s skin, help calm the baby from infantile colic/ ease’s tummy discomfort, relieves gas & bloating, and promotes peaceful sleep, strengthens mother and baby bond. Himalaya Baby Tummy Roll On is specially made with a blend of five natural oils to comfort the baby and provide relief from tummy discomfort and infantile colic associated with indigestion and gas. This gentle and effective tummy oil roll is easy to apply too. The soothing aroma of the oils gently calms and relaxes, promoting a restful all-night sleep. frequency -SOS Rout of Administration-Topical Duration- 03 Days 
Comparator Agent  NA  NA 
 
Inclusion Criteria  
Age From  0.00 Day(s)
Age To  36.00 Month(s)
Gender  Both 
Details  1. Subjects in the age group of 0 to 36 months.
2. Subjects with at least any one condition such as colic pain, indigestion, constipation, gas and bloating.
3. Subjects not using similar products during the study period.
4. Subjects who have not participated in similar clinical trial in the past 4 weeks
5. Subjects in general good health as determined from a recent medical history and physical examination.
6. Subject’s mother/legal guardian willing to give a voluntary written parent consent and agree to complete study activities and come for regular follow up with subject
 
 
ExclusionCriteria 
Details  1.A known history or present allergic condition that may require medical attention.
2.Chronic illness which may influence the cutaneous assessment.
3.Subjects not willing to stop the use of other tummy oil or any medication for this indication during study period

 
 
Method of Generating Random Sequence   Not Applicable 
Method of Concealment   Not Applicable 
Blinding/Masking   Open Label 
Primary Outcome  
Outcome  TimePoints 
To evaluate the safety and efficacy of Test Product in study population,Safety and efficacy will be assessed at the end of the study visit.  3 days, 
 
Secondary Outcome  
Outcome  TimePoints 
NA  NA 
 
Target Sample Size   Total Sample Size="500"
Sample Size from India="500" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Post Marketing Surveillance 
Date of First Enrollment (India)   26/10/2023 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="5"
Days="0" 
Recruitment Status of Trial (Global)
Modification(s)  
Not Applicable 
Recruitment Status of Trial (India)  Open to Recruitment 
Publication Details   N/A 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

STUDY OBJECTIVE: To evaluate the safety and efficacy of baby tummy roll on  in 0-36 month’s babies with at least any one condition such as colic pain, indigestion, constipation, gas and bloating.

 

STUDY DESIGN: An open label, post marketing observational study.

Study Methodology:

1. Parents/Legally Acceptable Representatives (LARs) of the baby will be provided with the Parent consent document and explained about the study in detail.

2. Babies who fulfil the selection criteria will be enrolled into the study after written parent consent.

3. The subject’s parent /LAR will be provided with The Himalaya baby tummy roll on, and they will be instructed on the use the product by the study doctor/ coordinator.

4. Assessments will be performed on Day 1/baseline and till symptoms resolution or day 3 + 1 day whichever is earlier (end of the study visit) as per the schedule of events.

5. If subjects score for Local intolerance is scored 1= Mild, 2=Moderate, 3=Severe, then the undesirable effect page to be completed.

6. All undesirable effects to be followed up till the event is stabilized or 7days whichever is earlier

Study duration: This study is planned till symptoms resolution or day 3 (+ 1 day) whichever is earlier.

Number of Subjects: 500 subjects will be enrolled.

Study Site: The study will be conducted at 20 sites.

Directions to Use: Apply directly on baby’s stomach around the naval area. Gently massage with hand if required. Keep using until baby gets better. 
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