This is an Open labelled, Non randomized, Single centric clinical trial to evaluate the effectiveness of Gandhaga Mezhugu in the management of Neerkiricharam (Urinary Tract infections). Urinary tract infections (UTIs) are common infections that affects any part of the urinary system, which includes the kidneys, bladder, ureters, and urethra. UTIs are typically caused by bacteria, with Escherichia coli (E. coli) being the most common culprit . Every year, around 150 million UTIs occur worldwide, leading to about $6 billion in healthcare spending. The usual treatment includes using antibiotics carefully. 

However, the growing issue of  becoming resistant to antibiotics is causing concern. This resistance can result in longer and more severe infections, increased healthcare costs, and a greater risk of complications. As antibiotic resistance continues to grow, researchers are exploring alternative treatment options to address UTIs effectively. Traditional herbal and mineral-based medicines have gained attention as potential alternatives to antibiotics. These traditional remedies, derived from plants, minerals, or other natural sources, have been used in various cultures for centuries to treat infections and promote overall health. 

Gandhaga Mezhugu, a herbo-mineral composite, has exhibited antibacterial properties against prevalent pathogens responsible for urinary tract infections in preclinical evaluations. This clinical investigation endeavors to systematically ascertain the efficacy of Gandhaga Mezhugu, an established therapeutic approach for multiple infection conditions. The study will be conducted in OP No. 11/12, Department of Gunapadam, Ayothidoss Pandithar Hospital, National Institute of Siddha, Chenna. Patients will be screened and recruited to the study based on the inclusion criteria. The sample size is 10 patients and the study period is 6 months. The outcome is assessed based on the urine culture and decrease/absence of the clinical signs and symptoms.