The population-based study from India to report on depression shows that the prevalence of depression was 15.1%. India is home to an estimated 57 million people (18% of the global estimate) affected by depression. Considering the huge burden and impact of depression and its importance as public health concern in developing and developed world, the World Health Organization declared depression: Let’s Talk, as the theme of World Health day on April 07, 2017 and lead a yearlong campaign on depression domains. There is also a need to study the course of depressive disorders in India so as to determine the need and duration of continuation treatment. The present study Randomized Control Trials will be carried out with aim to evaluate the efficacy of Panchagavya Ghrita Nasya in Vishada with special reference to Mild to Moderate Depression. For present study patients fulfilling the diagnostic criteria of Mild to Moderate Depression (ICD-10), between the age group of 18 yrs to 50 yrs with irrespective of Gender, religions, socioeconomic status etc. By using Sample size formula; Sample size found 57, so that 57 patients will be taken for study in each group. Total 114 numbers of patients will be selected and randomly divided into two groups, named as Group-A (Trial Group) and Group-B (Control Group) with Single Blind. Panchagavya Ghrita Nasya and Hingwadi Ghrita Nasya will be carried out in Group-A (Trial Group) patients and Group-B (Control Group) patients respectively. Trial and Control Drugs will be purchase from GMC certified pharmacy. Both drugs will be administered through nasal route with 3ml quantity in each nostril at morning hours continuous for 14 days. All SOP of Nasya Karma will be strictly followed during and after treatment. All the findings will be entered in Case Record Form (CRF) and for better understanding tabulation and graphical presentation will be done. Observations will be drawn on Before Treatment (0^th day), During Treatment (At 7^th day), After Treatment (At 14^th day) and Weekly Follow-up after completion of treatment (At 21^th day). Result of study will be calculated statistically with appropriate statistical method. Result will be drawn on basis of Criteria of assessment and Statistical analysis. Discussion will be done on the basis of observations and result obtained during the treatment. Summary will be drawn and whole thesis work will be summarized. Conclusion will be draw strictly on basis of statistical Analysis and will be unbiased.