Wound closure is a key element for successful healing of surgical sites and aids in reducing postoperative complications like pain, swelling, infection, etc. Literature has advocated use of sutures, surgical clamps, and adhesive agents for securing and stabilizing detached tissues for the subsequent satisfactory healing. Sutures are the most frequently used medical device for wound closure. They support tissue during the early phase of healing until it regains enough tensile strength. Regardless of the suture material origin, its essential role is to support the tissue until continuity of surface and enough tensile strength is regained during the process of wound healing. Good sutures require specific physical characteristics and properties, such as good resistance to traction, dimensional stability, lack of memory, good knot security, and sufficient flexibility to avoid damage to the oral mucosa. At the same time, they must avoid or limit bacterial adhesion and proliferation to those parts exposed to oral fluids, thereby avoiding contamination inside the wound. A good suture material must show a brief exudative phase and must not interfere with cellular proliferation or connective tissue organization. There are many suturing materials now available in the market. These materials are classified as braided multifilament and monofilament or bio absorbable and nonabsorbable. However, the selection of suture material for periapical surgery is often based on surgeons’ choices rather than scientific data and has not been extensively investigated. Hence, we propose a randomized controlled trial to compare efficacy of 4-0 prolene (3/8 reverse cutting) versus 4-0  PTFE suture (3/8 reverse cutting) in periapical surgeries in terms of postoperative complications, along with patient as well as surgeon’s satisfaction.