In this present generation the sedentary life style, lack of exercise, stress, life style modifications, change in dietary habits, urbanization precipitate the disease of Santarpanjanya vyadhis like as Prameha ¹. It told as one of the astamahaagadas ², Madhumeha is a Vataja Prameha ³ .Prameha is characterized by Prabhutha mutratva and Avila mutratva ⁴ The clinical feature like Madhura asyata , karapadadaha, suptata, mukha talu kanthashosha, pipasa-adhikya, alasya, tandra ⁵ can be correlated to the features of Type 2 Diabetes Mellitus.Diabetes Mellitus Type 2 and its complications pose a major threat to public health resource throughout the world. In today’s era, Type 2 Diabetes Mellitus has gained gigantic disgrace in recent times as it is fast becoming the world’s largest silent killer. In 2021, Approximately 537 million adults (20-79 years) are living with Type 2 Diabetes Mellitus.The total number of people living with diabetes Type 2 is projected to rise to 643 million by 2030 and 783 million by 2045⁶.  It has become utmost importance to find ways to combat this disease. Adults with Type 2 Diabetes Mellitus have a two-threefold increased risk of heart attacks and strokes. Diabetes is the cause of 2.6% of global blindness and it’s also a leading causes of kidney failure ⁷.

With an increasing incidence worldwide and due to chronic complications, there is need for effective management of Type 2 Diabetes mellitus. Ingredients of Lodhradi Kashaya possess tikta kashaya rasa, laghu guna, katu vipaka,pramehagna karma and Navaka guggulu possess katu tikta rasa, laghu ,rooksha guna,kapha vatahara, medohara ,amapachana karma. As madumeha is santarparnajanya vyadhi. Kapha and vata is main dosha and meda is main dushya involved in the manifestation of vyadhi. These formulations may help to act against it. The ingredients of both formulations are safe and easily available. This study is intended to evaluate the effectiveness of this combination in madhumeha .