Opioids are commonly used for analgesia and supplementary sedation during general anaesthesia and are the most widely used agents for the treatment of acute pain in the immediate postoperative period. Opioids provide effective analgesia and stable intraoperative hemodynamics, which are valuable during the perioperative period. However, the use of opioids during the perioperative period is risky. Opioids have many potential adverse effects, including respiratory depression, postoperative nausea and vomiting (PONV), and opioid-induced hyperalgesia (OIH). These complications are associated with delayed patient recovery, prolonged stay in the post-anaesthetic care unit (PACU), delayed hospital discharge, and unexpected hospitalization, all contributing to an increased burden on patients and resources.Perioperative opioids are administered for postoperative analgesia, and intra-operatively to control the sympathetic response to surgical stimuli, frequently as a surrogate for presumed pain.Opioid free anaesthesia (OFA) is a technique where the intraoperative use of systemic, neuraxial or intracavitary opioid is completely avoided. This new technique can provide intraoperative hemodynamic stability, immobility and postoperative analgesia without administering opioid drugs, and therefore the absence of the numerous side effects caused by opioids.³Opioids are used in general anaesthesia in various surgeries, though laparoscopic surgeries are considered relatively less painful and are associated with early recovery and lesser duration of hospital stay, they can cause severe pain, especially in four hours of the immediate post-operative period. This may be attributed to the peritoneal irritation caused by the carbon dioxide insufflation pressures, bowel handling by the surgeons or irritation caused by the residual or retained blood.⁴  Post-operative nausea and vomiting (PONV) are some of the most common complications after anaesthesia, often reducing patient satisfaction and prolonging the recovery and discharge from hospital. This is defined as nausea or vomiting that occurs during first 24 hours to 48 hours after surgery. Opioids can cause nausea and vomiting by stimulating the area postrema at floor of fourth ventricle.⁵The risk of PONV in the general surgical population is approximately 30%. In high-risk patient groups, or high-risk surgical procedures, the risk of PONV can be as high as 80%. PONV is a distressing experience for the patient and can have a significant impact on patient satisfaction. PONV may prolong post-anaesthesia care unit (PACU) stay and increase the risk of postoperative complications.⁶Lidocaine is an amide local anaesthetic that has analgesic, antihyperalgesic and anti-inflammatory properties. These properties of lidocaine are mediated by channel blockade, inhibition of G protein coupled receptors and NMDA receptors.⁷In addition to improving analgesia, perioperative lidocaine infusion shortens the duration of postoperative ileus by an average of 8 hours, and decreases the incidence of postoperative nausea and vomiting. ⁸ Ketamine, a phencyclidine derivative, an N-methyl-d-aspartate antagonist, blunts central pain sensitization at sub anaesthetic doses (0.3mg/kg or less). Ketamine has been increasingly used as an adjunct in the management of acute postoperative pain. Ketamine can inhibit the spread of nociceptive impulses to the brain. It can be administered by multiple routes, including intravenous, bolus injection, continuous IV infusion, epidural route and even wound infiltration. Ketamine is now preferred drug in many procedures like sedation for MRI, premedication in children, procedural sedation and acute and chronic pain management. Sub anaesthetic ketamine improves pain scores and reduces perioperative opioid consumption in a broad range of surgical procedures with a minimal risk of side effects. ⁹ Lacunae in the existing knowledgeExtensive search of literature reveals that, it has been found that no previous studies have        observed the effect of ketamine and lidocaine (OFA) on post-operative nausea and vomiting. Therefore, in this study we will compare the effect of fentanyl (opioid) versus opioid free anaesthesia with ketamine and lidocaine on post-operative nausea and vomiting in patients undergoing laparoscopic cholecystectomy.