Diabetic Neuropathy (DN) is an early and common complication affecting approximately 50% of the Diabetic patients. DN is caused by degeneration of myelinated and non-myelinated nerve fibers. It most commonly presents as diminished perception of sensation of vibration in distal part of limbs in glove and stocking pattern, impairment of perception of sensory stimuli, loss of tendon reflexes, etc. In patients showing symptoms predominant sensory abnormalities include paraesthesia in feet, pain in limbs, burning sensation in palms and soles, cutaneous hyperesthesia, numbness in feet. Muscle weakness and wasting develop in advanced stages of DN. Line of treatment in contemporary system of medicine focuses mainly on strict glycemic control with anti-convulsant (gabapentin, pregabalin) and antidepressants (amitriptyline, imipramine),opiates and in clinical practice analgesics, NSAIDs or corticosteroids are also used to relieve neuropathy pain. Diabetes and its complications are major causes of mortality, morbidity and poor quality of life. Long term use of anti-convulsant and anti-depressants produce many side effects- nausea, increased appetite, weight gain, loss of libido, erectile dysfunction, fatigue, drowsiness, insomnia, dry mouth, constipation, dizziness, agitation, irritability, etc. Anxiety, liver damage, brain damage due to hypoxia resulting from respiratory depression, development of tolerance and dependence on opiates. In Ayurvedic classicals there is no disease which can be correlated with DN, however detailed description of Prameha and its Upadrava available in classical treatises can help in understanding DN from Ayurveda’s perspective. Symptoms mentioned in Purvarupa and Upadrava of Prameha and Madhumeha show close resemblance with signs and symptoms of DN. Recent researches in Ayurveda have proved efficacy of various herbal and Herbomineral drugs in Diabetic Neuropathy. Ayurvedic medicines such as Ashwagandha,  Amalki,  Guduchi,  Shilajatu etc. evaluated through different preclinical or clinical studies. But still effective treatment is not available even on long term use of Ayurvedic or conventional management.