Global developmental delay is one of the major issues of concern during the early childhood which is unnoticed due to lack of early screening. The prevalence of Global developmental delay in children under 2 years of age in India is 1.5 to 2.5 % among the live births¹.Growth and development occurs simultaneously as a continuous process. Growth denotes the quantitative increase in the cell mass whereas Development is the gradual and systematic maturation of the nervous system. Maturity of the central nervous system, which is very much essential for a child to learn particular skill or to achieve a milestone. Growth being a quantitative parameter, growth retardations are identified at the earliest. Whereas normal developmental pattern is assessed using different developmental milestones, which are unnoticed due to lack of awareness and tendency to pretend it as normal even if there is lag or delay. Global developmental delay can be defined as the failure to attain the age-appropriate developmental milestones in 2 or more domains of development. Development depends on the functional maturation of the nervous system. As the brain matures, certain primitive reflexes are lost and specific milestones are achieved. If the primitive reflexes are persisting beyond the expected age of regression, it is an early indicator for developmental delay. Previous studies suggest that early screening, identification and early intervention has shown considerable improvement in the condition². Stimulation through Ayurveda procedures as an early intervention is a new ray of hope for a healthy future among the kids with developmental delay. Masthishka abhighata can be considered as one among the cause for developmental delay. In Bhaishajyaratnavali in the context of Mastishkachayaapachaya, Panchagavya ghrita is mentioned as Rasayana³. Hence the present study is planned to evaluate the effect of administration of Panchagavya ghrita in various forms (Basthi, Pratimarsha nasya & oral intake) as an early intervention along with external stimulation procedures like Sarvanga abhyanga and Parisheka.