After correction from the IRC&IEC, convenient sampling of patients attending opd services

during the study period mentioned, fulfilling the inclusion and exclusion criteria as listed will be

recruited for the study, after obtaining informed written consent under the guidance of the guide and

co-guide.

The nature, purpose and their roles in the study will be explained in detail, including the information

that their non-participation in the study would not affect the quality of their treatment that they are to receive and that they are free to exit the study at any time. After assuring that their responses would

remain confidential, an informed written consent for the same shall be obtained from all participants

Data will be collected using a pre-tested semi-structured proforma to collect sociodemographic details

about the patients participating in the study.

Patients based on convenience sampling will be divided into group A & group B . 

Both the groups detailed history will be taken and routine investigation like Hb,TC,DC,ECG, RFT, Urine Routine , Urine Culture, X-Ray KUB, USG KUB  and CT-KUB will be taken .

Participants were then randomly assigned into two groups, Group A and Group B. Patients in Group A received Silodosin 8 mg once daily, while those in Group B received Tadalafil 5 mg once daily. The assigned medication was continued until stone expulsion or for a maximum duration of four weeks. Throughout the study, all patients underwent regular assessments, including physical examinations, blood urea and serum creatinine levels, urine culture, and repeat radiological investigations as needed. In addition to the allocated treatment, patients were advised to increase fluid intake and were prescribed Diclofenac 50 mg orally during pain episodes.Patients were followed up for a period of four weeks, during which the primary and secondary endpoints were evaluated. The primary endpoint was the stone expulsion rate, while secondary endpoints included stone expulsion time, defined as the number of days from randomization to the confirmed expulsion of the stone, intervention rates such as the need for ureteroscopy in cases where spontaneous expulsion did not occur, the number of pain episodes experienced by the patient, and adverse effects associated with MET. Stone expulsion was confirmed through CT-KUB and X-ray KUB.