Brief summary of the results: The range of age among the recruited patients was 37-61 with a mean age of 50. Majority of patients belonged to 51-60 (52%) and 41-50 (32%) years of age. 58% were males and 42% were female. Increased visceral adiposity accounts for 65-75% of risk of hypertension in individuals with overweight/obesity. The BMI of recruited cases fall mainly under overweight (40%) and grade I obesity (32%) with minimum BMI of 20.30 (Normal), maximum BMI of 38.90 (Obese grade II) and mean BMI of 28.54 (overweight). Risk factors such as smoking (30%), tobacco chewing (2%), betel chewing (4%) and alcohol (14%) were surveyed during the time of recruitment. Among which, only smoking was found in considerable percentage of the subjects which might be likely due to dishonest responses with the fear of judgement (Berxi survey 2022). 44% and 38% of the patients showed poor and moderate physical inactivity establishing the causative association between physical inactivity and hypertension (A U Gamage 2021). About half of the patients had positive family history of hypertension (54%). Mixed diet pattern was followed among 78% of the subjects. The assessment of health status of the cases before and after intervention with VK using ISI, MoCA and SF-12 revealed significant improvement. VK markedly improved sleeplessness in patients from moderate severity insomnia (18.02) to no clinically significant insomnia (6.34) (p value <0.05 in paired T test). In MoCA scale, there was incremental improvement from 24.11 to 27.27 (No cognitive impairment) (p value <0.05 in paired T test). Short form-12 questionnaire before and after treatment showed significant improvement in physical health (from 39.28 to 51.46) and mental health (from 32.62 to 50.66) of the patients (p value <0.05 in paired T test). Patients with mean SBP of 162.12±8.68 and DBP of 98.32±7.71 were recruited in the study with minimum BP of 146/81 mmHg and maximum of 188/116 mmHg. Most of the patients belonged to vathapitham (24%), pithvatham (20%), pithakabham thegi (24%) and rasogunam (62%). Systemic examination according to Siddha parameters in accordance with symptoms such as profuse sweating, epiphora, redness of eyes, loss of appetite, ageusia, nausea, constipation/loose stools showed derangement of annamayakosam (94%), pranamayakosam (55%), manomayakosam (66%), abaanan (84%), samaanan (98%), analakam (94%), ranjakam (98%) and avalambagam (76%) which were improved markedly after intervention with VK (p value <0.05 in paired T test). In eight-step Siddha examination, sparisam (82%), naa (54%), malam (66%) and moothiram (48%) were affected. Among them, sparisam, malam and moothiram showed significant prognosis confirming the diuretic and laxative action of fruits of Vitis vinefera (B Salehi 2019). The blood parameters before and after treatment revealed meager improvement in Hemogloblin (from 12.40±1.52 g/dL to 12.99±0.99 g/dL) and HDL (from 39.48±3.53md/dL to 42.56±2.74mg/dL). Slight changes in Sodium (From 134.74 ± 4.94 mEq/L to 141.06 ± 2.05 mEq/L) and Potassium (From 3.36 ± 0.38 mEq/L to 3.98 ± 0.39 mEq/L) levels are noted. Even though Vitis vinifera was rich in fructose, there were notably better changes in the RBS (from 193.34±44.46mg/dL to 164.12±25.62mg/dL) and Cholesterol (208.52±34.97mg/dL to 181.46±16.01mg/dL) which may be due to confounding factors. On weekly assessment, there was marked improvement in SBP in second week of the trial whereas improvement in DBP were remarked only after the fourth week. Determining the potency of VK in control of hypertension (p value < 0.05 within the groups intercept in GLM repeated measures. There was notable improvement in clinical symptoms such as headache, sweating, insomnia, constipation and confusion with 50% of the patients responding to the treatment within 2 weeks of intervention.