1. What data in particular will be shared?
   Response - All of the individual participant data collected during the trial, after de-identification.
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   Response - Clinical Study Report
   Response -  Analytic Code
   
   
3. Who will be able to view these files?
   Response - Anyone
   


4. For what types of analyses will this data be available?
   Response - Any purpose.
   


5. By what mechanism will data be made available?
   Response (Others) -  thesis


6. For how long will this data be available start date provided 19-02-2025 and end date provided 19-03-2025?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

·      Currently most of the babies with mild to moderate respiratory distress managed with oxygen therapy via nasal cannula. Previous studies demonstrated that just five minutes of respiration using ambient gas with no heating or humidification in ventilated infants resulted in a significant decrease in both pulmonary compliance and conductance. Cool, dry air induces a bronchoconstriction response, increases resistance of airway.High-flow nasal cannula systems are designed with proper gas conditioning such as inline warming and humidification systems of supplied gas. Over last 2 decades there is increasing acceptance of HFNC among neonatal health care provider for management of respiratory distress in neonates.For this study, all cases satisfying inclusion criteria admitted in KIMS, Bhubaneshwar from time period of march 2023-Feb2025 will be considered.   Written consent from parents will be obtained after explaining them regarding intervention done. Baseline demographic maternal and neonatal characteristics will  be noted.Subjects will be assigned into two arms of study by simple randomisation as per inclusion and exclusion criteria.Newborns randomized to HFNC will be started on a flow rate of 4L/min and FiO2 adjusted to maintain oxygen saturations between 91-95%. Once initiated, the measures will be titrated as needed by the attending neonatologist to ameliorate signs of respiratory distress to a maximum flow rate of 8L/min and FiO2 of 60%. The nasal cannula size (0.2 cm or 0.3 cm outer diameter) will determined by the caliber of the subject’s nares).The NC flow will be started either at 0.5-1lit/min (acc. To WHO guidelines). The maximum flow to be titrated upto 4 l/min to attain target saturations 91–95% according to our institutional protocol. The size of nasal cannula will be determined by the caliber of the subject’s nares.Study participants who fail to respond to the assigned respiratory modality to be upgraded to either CPAP or mechanical ventilation based on the severity of RD and neonatologist’s decision.Study subjects follwed up for time required on oxygen support.Statistical Analysis done using collected data.