“A randomised control trial to assess the effectiveness of Nurse-led Myocardial infarction follow-up clinic on selected outcome variable of patients and caregivers of patients with Myocardial infarction attending Cardiology OPD in a tertiary care hospital”. The purpose of the study is to assess the effectiveness of Nurse-led Myocardial infarction follow-up clinic on selected outcome variable of patients and caregivers of patients with Myocardial infarction attending Cardiology OPD in a tertiary care hospital. The outcome variables include medication adherence, CVD related lifestyle factors, complications, biochemical and biophysiological profile, patient satisfaction and the caregiver burden of the patients. The study’s findings will help understand the benefits of having a healthy lifestyle and modifying the risk factors to prevent further cardiovascular events after a myocardial infarction. The post PTCA patients getting admitted in the ward will be scrutinised based on the inclusion and exclusion criteria and subjects will be randomly selected with the help of a computerised randomization approach. After obtaining the informed consent, SNOSE technique will be used for allocation concealment by the Senior Nurse. The experimental group will receive discharge counselling and a discharge booklet (to address gaps in knowledge and to make it easier for the patient to remember important and relevant points) in the ward in a specified room where there will be a one-to-one interaction with the patient and caregiver. The Nurse researcher will follow- up the patient till discharge and give reinforcement of expected behaviors. The Senior Nursing officer gets the baseline data while the subjects are in the ward. Patients of the intervention group also receive telephonic reinforcement by the Nurse researcher once a month till 3 months and reminder to come for follow-up with the blood investigations report in OPD AIIMS Nagpur at 1 month, 3 month and 6 months. On the upcoming OPD visits, the research associate will send the Experimental group patient to the Nurse-led MI follow-up clinic and then to the Cardiologist’s clinic, while the control group subject will be sent to the Cardiologist’s clinic only. On each follow up visit, the outcomes (O2, O3 and O4) will be assessed. The experimental group patients will be able to contact the researcher anytime for any queries or clarifications. All the relevant information will be given in written form to the caregiver, for reference at home and the checklist is encouraged to be filled out to avoid loss of information due to memory loss during long-term follow-up.