Breast cancer has seen a rapid rise in incidence, becoming the leading cause of global cancer incidence in 2020. Choice of treatment is Modified Radical Mastectomy (MRM). Most commonly encountered complication of MRM is formation of seroma, which can be prevented by the use of closed suction drainage system, preferable active suction drainage.

This Prospective Randomised controlled study attempts to compare the efficacy and the morbidities associated with use of combined axillary and pectoral drain versus single axillary drainage post modified radical mastectomy.

Objectives: Assessing the incidence of seroma formation, post op wound infection, duration of drain insitu, drain output and length of hospital stay

Women with histologically proven breast cancer, stage 1,2 3 not undergoing neoadjuvant therapy undergoing MRM, will be included in the study and will be randomized into 2 groups using envelope method, Group A (single axillary drain) and Group B (combined axillary and pectoral drainage), with 78 patients in each group (total sample size 156)

Standardized operative procedure and post-operative course will be followed in all patients in both groups in drain emptying and dressing

Patient will be followed up postoperatively to evaluate drain output, incidence of surgical site infection, flap necrosis, seroma formation (clinically and quantified with ultrasonography), timing of drain removal and total duration of hospital stay.

Data will collected and analyzed with SPSS version 28.

 The quantitative data will be reported as mean and standard deviation. Differences between means will be tested with Student’s t-test and the incidence of seroma, flap necrosis and wound infection will be reported as number and percentages and Fisher’s exact test/ Chi square test will be employed.