1. What data in particular will be shared?
   Response - All of the individual participant data collected during the trial, after de-identification.
   


2. What additional supporting information will be shared?
   Response - None of the above
   
   
3. Who will be able to view these files?
   Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.
   


4. For what types of analyses will this data be available?
   Response - For individual participant data meta-analysis.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [snamratarao@yahoo.co.in].
   


6. For how long will this data be available start date provided 11-10-2025 and end date provided 10-10-2028?
   Response - Beginning 9 months and ending 36 months following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

Chronic kidney disease (CKD) is an increasingly common cause of morbidity and mortality worldwide. While diabetes mellitus and hypertension account for a majority of CKD, a proportion of CKD burden especially in tropical countries like India, is accounted for by CKD of undetermined etiology (CKDu). (1) CKDu has been described in endemic hotspots globally for last few decades, appearing as a chronic interstitial nephritis in predominantly agricultural communities in tropical climates such as India, Sri Lanka, and many South and Central American countries. Majority of reports of CKDu in India come from southern India, where the climate remains hot and humid through the year, however, CKD hotspots have been described in Kanpur from Uttar Pradesh, and in Chattisgarh and Punjab too, where temperature and relative humidity dip significantly in the winter months. Whether these northern Indian hotspots correspond to CKDu or not, is presently unclear. (2)

Presently, the department of Nephrology runs six outpatient clinics a week catering to patients coming from the neighbouring districts in eastern Uttar Pradesh, with a hospital-based registry for patients with CKD, a proportion of whom correspond to CKDu. With the current advances in geolocalisation, identified cases of CKDu can be mapped down to their street and home address. At the outset, the study will estimate the prevalence of CKDu among the patients visiting this hospital, and later might identify CKDu hotspots if any, in this region, which is climatically and ethnogeographically different than areas previously identified.