Dry eye disease is defined as “a multifactorial disease of the tears and ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability with potential damage to the ocular surface. It is accompanied by an increase in the tear film’s osmolarity and sub-acute ocular surface inflammation." Keratoconjunctivitis sicca(KCS), keratitis sicca, Sicca syndrome, Xeropthalmia, dry eye disease (DED) ocular surface disease (OSD), dysfunctional tear syndrome (DTS). The disruption of the lacrimal functional unit is known to cause dry eye. Lacrimal glands, the ocular surface including cornea, conjunctiva, eyelids, meibomian glands, ocular nerves, and goblet cells make up the lacrimal functional unit. Inclusion criteria - Patients of either gender > 18 years of age, Patients diagnosed with moderate dry eye disease (score 9-13) according to Khurana’s scoring system, and Patients willing to give written informed consent..   Exclusion criteria Patients with Any structural abnormalities, Pregnant and lactating, women,, Hypertension, Glaucoma, Diabetes, History of allergy to study medication. Group A- 25 patients with polyethylene glycol eye drops 0.1% TDS for 6 weeks and Group B- 25 patients with sodium hyaluronate eye drops 0.1%TDS for 6 weeks.Schirmer-1 test ,Tear break-up time, Rose Bengal staining score, Fluorescein staining, Lissamine green staining,(0, 2, and 6 weeks).Goblet cell conjunctival impression cytology ,OSDI (0 and 6 weeks). likert scale and safety assesment  2 and weeks.