OA is a clinical problem related to pain, it has been clinically noted that there is a significant inflammatory soft tissue contribution to the severity and frequency of OA pain. OA is one of the most frequent causes of chronic pain, at the initial stage the pain at the OA joint occurs during movements and loading of the joint, which is increased during activities. At the later stages, the pain seems to occur even during nights and without loading the joint or performing the movements. Thus, it is noted that there is gradual increase of pain with OA progression. As the condition becomes chronic patients will avoid physical activity due to fear of movement and worsening of pain. Various scales and/or questionnaires are used to measure pain intensity, kinesiophobia, depression, self efficacy and quality of life. The commonly used outcome measures in chronic knee osteoarthritis is The Knee Injury and Osteoarthritis Outcome Score (KOOS), which is used to assess patients opinion about their knee and associated problems. Visual analogue scale (VAS) is a valuable instrument used to assess pain intensity and changes due to therapy when respondents are given good instructions and the limitations are borne in mind. Hospital Anxiety and Depression scale (HADS) consists of anxiety and depression subscales which is easy, simple and reliable generic self reported tool. General Self Efficacy Scale is used to assess the strength of individual’s belief in his or her own ability to respond to difficult situation and to deal with any associated obstacles. Tampa scale of Kinesiophobia is used to assess fear and phobia in individuals with musculoskeletal pain. Individuals with chronic musculoskeletal pain conditions, like OA avoid to perform the daily physical activities that are been motivated by fear of pain rather than the actual pain. Pain is more over accepted as a key symptom of knee OA, and is not correlated with OA related structural changes. Kinesiophobia in patients with knee OA is been reported to increase the rate of disability. It is a central factor in the pain process which develops from acute to chronic stages. Kinesiophobia is referred to as a psychological fear, which is secondary to the bodily damage that is caused by activities of daily living, when the patient is worried about pain. It is determined that when a painful experience is interpreted as threatening, they can generate catastrophizing cognitions which results in more pain and re-injury. The common symptoms seen in knee OA are pain, stiffness, swelling, muscle weakness, crepitation, locking sensation, decrease range of motion and deformity. Knee OA negatively affects daily life by causing deterioration in the function and quality of life. And also, patient with knee OA has a significant impact on the psychological factors like Kinesiophobia, Depression, Catastrophizing, Anxiety etc. In long term pain due to the negative effects on pain and function, Kinesiophobia and pain catastrophizing decreases the efficiency of treatment and patient satisfaction. Kinesiophobia has been studied in number of conditions such as chronic low back pain, chronic fatigue syndrome, and shoulder pain and even in elderly populations. It is been found that level of pain and pain related fear are significantly associated with functional limitations in patients with OA. A study done by Elboin-Gabyzon and his colleagues on gender difference in terms of pain perception and functional ability in OA knee patients has concluded that though the prevalence of OA knee in females is higher but still they had lower functional abilities compared to male subjects. The reason for this was stated as the self reported measures were influenced by psychological factors of chronic pain like catastrophizing, depression and self efficacy in females. In spite of the higher prevalence of knee  OA among females because of estrogen hormone during and post menopause, gender-related differences among patients with knee OA have received little attention. Also, there is dearth of literature in relation to gender difference amongst various symptoms of chronic pain in OA knee. Hence, there exist a need to compare the pain intensity, function and psychological symptoms in Males and Females in OA of Knee.