Propofol (2,6-di-isopropyl phenol), has become the most popular intravenous anesthetic drug for induction, maintenance of anesthesia, and sedation. However, pain on propofol injection is a problem. The incidence of pain following propofol injection varies between 28-90% in adults if a vein on the dorsum of the hand is used. Various techniques to mitigate this pain include administration in larger vein, pre-mixing with lignocaine, pre-administration of sub-anesthetic doses of ketamine, using a mixture of medium and long-chain triglycerides in the carrier emulsion, etc. However, even with multimodal techniques, pain on propofol injection is not abolished completely. It has been shown that pre-administration of colloid prevents contact activation by propofol, which may lead to reduced pain during injection. With this background and in search for the ideal dose, we will be conducting a study to compare the effects of pre-administration of 50ml and 100ml 6% Hydroxy Ethyl Starch (HES) in attenuation of propofol injection pain during induction of anesthesia. This study will be a randomized double blinded, comparative study, to be carried out on 180 patients, of ASA I and II undergoing elective surgery under general anaesthesia. The patients will be randomly divided into three groups of 60 each. Group H50 (n=60) will receive 50ml hydroxyethyl starch. Group H100 (n=60) will receive 100 ml hydroxyethyl starch. Group S (n=60) will receive 50 ml of normal saline. The pain response will be assessed and recorded using a 4- point Verbal Rating Score. All the findings and observations made during the entire study will be tabulated, graphically depicted wherever possible, statistically analyzed and inference will be drawn to evaluate and compare the effect of pre-administration of 50ml and 100ml hydroxyethyl starch for reduction of pain on propofol injection.