1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   Response - Clinical Study Report
   
   
3. Who will be able to view these files?
   Response - Researchers who provide a methodologically sound proposal.
   


4. For what types of analyses will this data be available?
   Response - Any purpose.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [ruchika.roongta@gmail.com].
   


6. For how long will this data be available start date provided 25-01-2025 and end date provided 25-01-2028?
   Response - Beginning 9 months and ending 36 months following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

Dental caries affects nearly 3.5 billion people globally. As most patients report in advanced stage, 70% of them need root canal treatment (RCT) for caries management. However, RCT is a destructive procedure resulting in complete removal of vital tissues of the tooth. Vital Pulp Therapy (VPT) has merged as an economical and conservative alternative to RCT. However, at present the main deterrent for VPT to be considered as first line of treatment for carious teeth is lack of high-quality evidence and objective criteria for case selection. Hence, the aim of this prospective clinical study is to evaluate the outcome of vital pulp therapy procedure in symptomatic cariously exposed posterior teeth with Quantitative Light-induced Fluorescence (QLF) assisted caries removal and correlate the level of locally expressed inflammatory biomarkers in pulpal blood with the treatment outcome. The proposed study shall be conducted in the Department of Conservative Dentistry & Endodontics, at Maulana Azad Institute of Dental Sciences, New Delhi on 120 patients referred to the department for the management of their symptomatic carious permanent molar teeth. Informed consent will be obtained from all patients prior to treatment followed by taking history.  Patient will be randomly allocated to QLF or Non QLF group. All the treatment procedure will be done by experienced endodontists under dental operating microscope using enhance treatment protocol recommended by European society of Endodontists (ESE). The cavity will be prepared using a sterile high-speed round bur, whereas carious removal will be performed using a slow-speed round bur and a spoon excavator. After caries removal, prepared cavity will be scanned with QLF in QLF group. The infected dentin indicated by QLF analysis will be further removed. Complete removal of infected dentin will be ensured by scanning prepared cavity again before pulpal exposure. In both the Experimental groups, partial pulpotomy will be attempted first. If bleeding cannot be arrested even after 10 minute using 2.5-3% Sodium hypochlorite, full pulpotomy will be performed. Patient will be regularly followed up for post operative pain assessment (1,3,7,14 days), clinical and radiographic treatment outcome (Minimum 1 year follow up).