In the present ‘post-antibiotic era’, understanding the prevalence of Carbapenem-resistant GNBs is of utmost importance since it is the first step toward effective antimicrobial stewardship and prevention and control of infection. Awareness regarding the consequence of CRE infections resulting in high mortality and morbidity and collating the real-world data are critical as these help in making evidence-based decisions that may improve clinical outcomes. Further, this study will help develop an understanding of the socio-economic implications of the increased average length of hospital stay, loss of income and out-of-pocket expenditures. WHO has also identified Carbapenem-resistant GNBs as critical pathogens, and data from continuous monitoring is crucial for urgent drug discovery, research and subsequent development programs. This study will help in understanding the microbiological diagnosis of antibiotic resistance, comprehending clinical-microbiological correlation and treatment planning with a very limited arsenal of antibiotics. From this perspective, the study is planned to understand the microbiological nature of bloodstream infections in the laboratory, with a focus on the phenotypic and genotypic determination of antibiotic resistance and clinical correlation to the treatment outcome.