Though Post Operative Sore throat is a minor complication after General Anaesthesia, but it poses immense discomfort to the patient.It leads to cough which may cause strain at the suture site eventually effects the healing. In this era of day care surgery and enhanced recovery of the patients after the surgery, patient should be able to return to his/her routine activity without any discomfort/limitation as early as possible. Though considered as a minor complication by many clinicians,sore throat/hoarseness/cough in the post operative period poses high risk of patient discomfort and dissatisfaction after the surgery. Total incidence of post operative sore throat is around 68%.Various pharmacological and non pharmacological methods were tried with variable success rate.The underlying cause for POST might be trauma to the oropharynx, base of tongue, or posterior pharyngeal wall or inflammationsecondary to trauma caused by airway device used. Trauma to epithelial layer or deeper layers of vocal cords may initiate inflammation leading to edema. Anti inflammatory drugs will be effective in countering the inflammation caused by the trauma to the airway/ mucosa. Steroids are one such group of drugs which help in reducing the inflammation caused by the initial insult/trauma. Hence usage of steroids in various formulations and various routes were tried to attenuate the initial inflammation caused due to endo tracheal intubation in the airway mucosa eventually hypothecating that there would be reduction in incidence of post operative sore throat.Steroids reduce the production of inflammatory mediators, prostaglandins, and leukotrienes. The mechanism behind this is inhibition of phospholipase-A2 through production of calcium-dependent phospholipid-binding proteins known as annex-ins and cyclo-oxygenase. Hence, the efficacy of two highly potent steroids betamethasone and dexamethasone given topical and nebulised forms respectively prior to intubationis compared in reduction of incidence of POST.There is a limited literature available in testing the efficacy of highly potent topical betamethasone preparation when applied to the Endotracheal tube. So, we attempted to study the efficacy of topical Betamethasone gel when compared with nebulised dexamethasone in reducing the incidence of post operative sore throat.