HPMC EYE WASH (Hydroxy Propyl Methyl Cellulose Eye Wash )  are used to relieve eye discomfort and soreness due to environmental factors Polyhexamethylene biguanide binds to the negatively charged phospholipids found in the microbial plasma membranes causing membrane disruption and cellular lysis. Hypromellose prolong the retention time and improve adhesion of synthetic tears to the cornea and conjunctiva. Disodium edetate is a cationic chelating agent that binds free metals and enhances antimicrobial activity of disinfectants.

Potassium chloride acts as tonicity agents that maintain the osmolarity to that of the tear film and Disodium Hydrogen Phosphate and Sodium dihydrogen Phosphate Dihydrate Buffering agents added in the product maintains the pH to that of the tear film properties. Phosphate buffer (disodium hydrogen phosphate & Sodium dihydrogen phosphate dehydrate are the most physiologic of common buffers; they are non-toxic to cells and mimic certain components of extracellular fluids. Sodium Hydroxide is an alkalizing agent. Sodium chloride is an Electrolyte added to maintain osmolarity as high osmolarity products pull water from epithelial cells.

HPMC EYE WASH (Hydroxy Propyl Methyl Cellulose Eye Wash) can be used to protect the eye from irritations/ soreness/discomfort due to continuous use of computer/TV/exposed pollution/dry environment and the discomfort of using contact lenses.

There will be 4 follow up visits expected after using the product:

  1^st Visit - After 8 days of using the product

  2^nd Visit - After one month of using the product

  3^rd Visit - After two months of using the product

                    4^th Visit - After three months of using the product 

Intended purpose	Persons who experience dryness, soreness, Itchiness, discomfort of eyes due to the continuous use of computer/TV/exposed pollution/dry environment use the Eye wash to soothes and refreshes the eyes
Intended users	Persons who experience dryness, soreness/itchiness/discomfort of eyes due to the continuous use of computer/TV/ exposed pollution /dry environment.

This study will be a prospective, multi-centric, non-randomized study. The subjects visiting the study centers with the complaints such as eye dryness, Itchiness, discomfort of eyes due to the continuous use of computer/TV/exposed pollution/dry environment will be screened at Day 0 and if they meet the inclusion and exclusion criteria, then they will be selected for the study. A total of 72 subjects will be recruited for this study for the HPMC EYE WASH (Hydroxy Propyl Methyl Cellulose Eye Wash). 

Result-

A PMCF study of Hydroxy Propyl Methyl Cellulose Eye Wash was conducted at Marigold Hospital, Bangalore, in 72 subjects (14 male, 58 female), aged below 20 years (n=2), 20–40 years (n=62), and 40–60 years (n=8). The target population included individuals experiencing ocular irritation, dryness, itching, strain, redness, watering, burning, or discomfort due to prolonged screen use, pollution, or dry environments. Clinical safety was confirmed as no adverse events, complications, or residual risks were observed during the 90-day follow-up. Intraocular pressure (IOP) and visual acuity (UNDVA, BCDVA) remained stable with no statistically significant variation from baseline (p>0.05), unaffected by age or gender, confirming product safety. Clinical performance outcomes demonstrated consistent improvements in eye comfort, soothing effect, and visual performance, with subjects reporting relief from soreness and eye fatigue. The majority of participants noted that the product’s effects lasted for 5–8 hours, in some cases extending throughout the day.