Chronic Urticaria (CU) is a common dermatological condition affecting an estimated 15-20% of the general population at least once during the life time. Urticaria causes inconvenience in family structures, compromising performance at work, school, and negatively impacting on leisure activities.

Urticaria is a mast-cell-driven disease. Histamine and other mediators, such as platelet-activating factor (PAF) and cytokines released from activated mast cells, result in sensory nerve activation, vasodilatation, and plasma extravasations as well as cell recruitment urticarial lesions.

Contemporary modern medicine does not have complete cure for Urticaria. Modern second-generation antihistamines are considered as the first-line symptomatic treatment for urticaria and these medicines have undesirable side effects such as drowsiness, dry mouth, weight gain and increased resistance to infections.

The symptoms of urticaria is comparable to sheetapitta. The main focus of the present therapies aimed at symptomatic relief. Panchakarma therapies helps in cleansing the body and also helps in detoxification. The hyper immune response is seen in urticaria is countered effectively with panchakarma therapies. Virechana karma is one among the panchakarma therapy. Virechana Karma is a simple method of shodhana therapy which acts on sleshmasamsrusta pittaja vyadhi. After samshodhana, udwarthana can be used to ensure better results in sheethapitta vis-a vis Urticaria.

This study is designed as single arm study in patients with Virechanottara Udwarthana. After screening, patients will be enrolled if they satisfy inclusion and exclusion criteria. The patients will be assessed clinically on baseline, 10^th and 50^th day of treatment. This includes subjective assessment of general wellbeing, weekly UAS7 scores and physical examination. The total duration of treatment will be 50 days. Laboratory parameters for safety assessment will be conducted at baseline and on completion of the protocol therapy.