Melasma is common hypermelanosis that typically occurs on sun-exposed areas in the face. The overall prevalence of Melasma in women varies by geography and population between 1.5% and 33.3%. The estimated prevalence of melasma in pregnant women is up to 70%. The prevalence of melasma in men as suggested in one simple survey is approximately 20%. It is a cosmetic issue that sometimes cause great psychological suffering. As per one study, which showed that melasma associated with significant impact on health-related quality of life. It is characterized by sharply demarcated, blotchy, brown maculae, usually symmetrical on the cheeks, forehead, sometimes on the upper lip and neck. According to Unani system factors affecting kalaf  includes frequent exposure to excess abnormal external heat;  Dam-e-Muharraq (charred blood), Sauda-e-Muharraq (charred melancholic blood),  Ghiza-e-Kaseef (indigestible food), constant local pressure, pregnancy, liver disease i.e. Du’f al-kabid (liver atony) and Sughàr al-kabid. Although Melasma is asymptomatic it is disfiguring skin disease that has a negative impact on life and the self-esteem of effected individuals and causes distress in the patients as it mainly affects the face. It affects their psychological and emotional wellbeing and often feel bothered, frustrated, embarrassed, and depressed about their skin appearance.

The physician described various regimenal and pharmacotherapies for the management of Melasma in detail. The Pharmacological action of zimad in present study exhibits: Jali (detergent), qabiz (astringent), Qasir (Scaling), Ghassal (irrigator), Mubassir (vesicant), Muhammir (rubifecient), Raade-Mawaad (divergent), Mughazzi (nutrient), muhalil-e-awram (anti-inflammatory), antioxidant, antimicrobial, dafa-e-quba (antifungal), mana-e-sartan (anticancer), mana-e-qurooh (antiulcer) properties.

Therefore a clinical trial entitled ’Efficacy of Rewandchini with Asl as Zimad in Kalaf (Melasma) - A Randomized controlled trial’ is contemplated to evaluate the efficacy of rewandchini with Asl with the objective of improvement in skin lesions and to improve the quality of life of the sufferers of Melasma.