IV access is an important component of patient care, especially for those who require long-term IV treatment like chemotherapy and supportive care. Many studies done in other parts of the world have documented the importance of IV access for cancer care as part of routine practices. For pediatric patients, IV access is challenging because of their small caliber veins, anatomical variations, along with the child’s anxiety, and withdrawal add to the difficulty of vascular access. Children undergoing cancer treatment require IV access multiple times during their treatment. Trained personnel for IV access for pediatric cancer patients may reduce the chances of multiple attempts, thus less pain and shorter duration for vein puncher. There are many devices available for vein access including the ultrasound (US) guidance device for intravenous (IV) access. This has now emerged as routine practice in many settings for central line placement and difficult peripheral IV access. This is an under-researched area in developing countries like India and the data for current practices lacks for most of the developing countries. This study aims to explore the current practices in two cancer centers in New Delhi that provide treatment for pediatric cancer patients. Based upon the findings from the baseline study, a center-specific intervention for each participating center will be done. As an intervention, a Central Venous Catheter bundle (CVC Bundle) comprising of equipment, staff, training, SoPs, and an Ultrasound (USG) locator shall be used at the participating center. The intervention CVC package will be developed building on the services available currently at the participating centre with support from Cankids. The impact of the intervention will be assessed by carrying out a post-intervention assessment of phlebitis and quality of life in the participating centers.