1. What data in particular will be shared?
   Response - All of the individual participant data collected during the trial, after de-identification.
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   
   
3. Who will be able to view these files?
   Response - Researchers who provide a methodologically sound proposal.
   


4. For what types of analyses will this data be available?
   Response - Any purpose.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [naduvinamanichaitra@gmailcom].
   


6. For how long will this data be available start date provided 28-05-2022 and end date provided 28-05-2030?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

Ashmari is one of the disorders of Mutravaha Srotas and it is included in Astamahagada.

The word ‘Ashma’ means ‘stone’ and ‘Ari’ means ‘enemy’. The formation of stone which cause great pain and suffering to the body like an enemy is called Ashmari.

Renal Calculi are one of the most painful and common disorders of urinary tract, which are solid crystals that form from dissolved minerals in urine, caused by both environmental and metabolic problems.

Acharya Sushruta explains Lakshanas of Ashmari as pain in Nabhi (umbilical), Basti (bladder), Sevani (perinealraphe), and Mehana (penis), Mutradharana (obstruction in flow of urine), Sarudhiramutra (haematuria), Mutravikirana (scattering of urine), Gomedakaprakasha (passing of urine like Gomeda), Sasikata (with gravels) and Visrujati (turbid).

The lifetime risk of kidney stone is estimated to be between 5% and 10% with reoccurrence rate as high as 50%. Renal calculi occurs in people of all parts of the world with lower time risk of 3-15% in the west 25% in Asia and 20% in India. Renal calculi are quite common and usually affects people who are between 20-60 years of age, they affect male more than female. It is estimated that renal colic affects about 10-20% of male and 3-5% female.

In India, Kidney stone Disease is prevalent, with an expectancy of 12% in total population reported to be prone to urinary stone. Of this 12%, 50% of the population is affected by renal damage, which even leads to a loss of kidneys.

 Acharya Sushruta has described various medicines and surgery. Medical treatment has been advised to be undertaken in the early stage of the disease. Indication for the surgical management has mentioned along with the note of caution regarding complication.

In the context of Ashmari Chikitsa, Acharya Sushruta has advised that surgery to be undertaken only on failure of conservative treatment and when death becomes inevitable if not treated surgically.

Acharya Sushruta explained the use of Gokshura with Madhu and Aviksheera as Anupana in Ashmari Chikitsa.Gokshura has properties like Ashmarihara and Basti Shodana.

  Kataka explained in Dhanvantari Nighantu Chandanadi Varga is taken for the study. Acharya while explaining the properties of Kataka states, it is Vaariprasadana, Chedaniya Vishagna and Muootrashmarihara. By going through the individual Guna Karma of Kataka it is said to be Tridoshahara.

The study will be carried out to evaluate the effect of Kataka Beeja Churna and Gokshura Churna in Mutrashmari.