Cushing’s syndrome (CS) is one of the most enigmatic endocrine disorders. It is important to confirm the ACTH dependent hypercortisolism and distinguishing Cushing’s disease from ectopic CS.  Most of the ACTH dependent CS are caused by Cushing’s disease, of which majority are due to microadenoma being less than 6 mm. Visualizing tumors within 10 mm pituitary and confirming its functional status is challenging. Long-term remission/cure is determined by the correct functional and anatomical delineation of corticotropinoma (pituitary-tumor). The treatment of choice in Cushing’s disease is pituitary microsurgery. However, pituitary-tumor is not well delineated within the sella in 30-40% using currently available investigations especially MRI and inferior petrosal sinus sampling, which affects intra-operative navigation for selective adenomectomy and influence remission rate.

Now we have developed a non-radioactive (cold kit) formulation. So that the same may be available to all hospital based radiopharmacy for quick and a facile synthesis of PET tracer, Ga-68 mDesmo, for lateralizing pituitary adenoma (Cushing’s disease) and differential diagnosis of ACTH-releasing pituitary adenoma (Cushing’s disease) from the of ectopic ACTH-secreting tumors by non-invasive molecular imaging (PET/CT).