Gingival recession is a highly prevalent condition which results in exposure of root surface to the oral environment. It is usually associated with impaired aesthetics, hypersensitivity, tooth structure loss (root caries and non-carious cervical lesions) and difficulty in plaque control. Various surgical techniques have been proposed for the treatment of gingival recession. For most of the soft-tissue augmentation surgeries, adjunctive use of CTG is deemed as the gold standard treatment. However, its harvesting is often associated with increased patient morbidity and risk of postoperative complications. Researchers have been continually attempting to develop new biomaterials to overcome these limitations. A newly developed volume-stable collagen matrix (VCMX) has recently been introduced. However, at present it remains unknown to what extent VCMX may represent a valuable alternative to CTG in treatment of multiple GRs. Also, knowledge about influence of VCMX on early and late wound healing events in root coverage procedures is currently missing. Our study will determine the clinical efficacy of VCMX in treatment of multiple GRs and also assess the healing dynamics at molecular level through evaluation of angiogenic and wound healing biomarkers expressed in gingival crevicular fluid (GCF).