Maintenance of primary dentition is imperative for the development of arch form, esthetics, function, mastication, and normal eruption of permanent teeth. Premature loss can cause various problems such as ectopic eruption, space loss for the successor permanent teeth, alterations in speech, and impairment of function. Hence, decayed primary teeth should not be extracted and treated whenever possible. Pulpectomy is generally recommended as a treatment of choice in such cases. But several factors make conventional pulpectomy arduous. The typical primary tooth morphology (tortuous root canals, presence of multiple accessory canals, ramifications, and ample medullary bone spaces that favor dissemination of infection) often presents a challenging task to the clinician. In addition to that, obtaining a hermetic seal is difficult due to the lack of apical closure following physiologic root resorption owing to the proximity of the developing permanent tooth germ to the roots of the primary teeth. A further challenge presented to the dentist in rendering effective endodontic treatment is the behavior management of uncooperative children. Thus to overcome these hurdles, the concept of lesion sterilization and tissue repair (LSTR) which involves the topical placement of triple antibiotic pastes (TAPs) evolved which aims to disinfect the canal space thus promoting repair of damaged tissue. LSTR involves the use of three antibiotics/antibacterial drugs namely, Metronidazole, Ciprofloxacin and Minocycline with macrogol (M) as the ointment base and propylene glycol (P) as the carrier. The prime concern regarding the use of triple antibiotic paste is the discoloration caused by minocycline. To overcome this, alternative medications such as clindamycin, cefaclor, amoxycillin have been proposed. The American Association of Endodontists (AAE) 2018 protocol recommends Triple Antibiotics Paste (TAP) should be mixed equally (1:1:1) to a final concentration of  1 – 5 mg/ml. At this concentration, TAP is conducive with stem cell survival and proliferation and also effective in eliminating microorganisms within the root canal. But no standardization regarding the dosage of drugs used in the antibiotic combination of LSTR in deciduous teeth has been done till date.

An in vivo interventional study will be conducted among children of age group 5-9 years with indication for pulp therapy using Modified Triple Antibiotic Paste (Ciprofloxacin, Metronidazole and Amoxicillin) with different concentrations (0.5 mg/ml, 2.5 mg/ml and 5 mg/ml) for LSTR of primary molars and comparative evaluation of clinical and radiographic success of LSTR will be done at specific time intervals.