CTRI/2022/05/042880 [Registered on: 27/05/2022] Trial Registered Prospectively
Last Modified On:
28/09/2025
Post Graduate Thesis
Yes
Type of Trial
Interventional
Type of Study
Homeopathy
Study Design
Randomized, Parallel Group, Multiple Arm Trial
Public Title of Study
Clinical Study to Evaluate The Efficacy Of Higher Potency Repetition Against Same Potency Repetition Of Homoeopathic Medicine in Choronic Sickness
Scientific Title of Study
A Prospective, Randomized, Single Blind, Four Arm Clinical Study to Evaluate the Efficacy of Higher Potency Repetition Against Same Potency Repetition of Individualised Homoeopathic Medicine Having Alternating Action on Non-Improving Patients with Chronic Sickness
Trial Acronym
Secondary IDs if Any
Secondary ID
Identifier
NIL
NIL
Details of Principal Investigator or overall Trial Coordinator (multi-center study)
Name
Dr Ashutosh Tripathi
Designation
Medical Officer (Homoeopathy)
Affiliation
All India Institute of Medical Sciences, Raipur
Address
Deaprtment of Homoeopathy, All India Institute of Medical Sciences, Raipur, Chhattisgarh
Raipur CHHATTISGARH 492099 India
Phone
8518887337
Fax
Email
drattripathihmo@aiimsraipur.edu.in
Details of Contact Person Scientific Query
Name
Dr Rakesh Gohel
Designation
Professor Organon of Medicine
Affiliation
Parul University, Vadodara Gujarat
Address
Deaprtment of Organon of Medicine, Jawaharlal Nehru Homoeopathic Medcial College, affiliated to Parul University, PO Limda, Waghodia
Vadodara GUJARAT 391760 India
Phone
Fax
Email
rakesh.gohel@paruluniversity.ac.in
Details of Contact Person Public Query
Name
Dr Ashutosh Tripathi
Designation
Medical Officer (Homoeopathy)
Affiliation
All India Institute of Medical Sciences Raipur
Address
Deaprtment of Homoeopathy, All India Institute of Medical Sciences, Raipur, Chhattisgarh
Raipur CHHATTISGARH 492099 India
Phone
8518887337
Fax
Email
drattripathihmo@aiimsraipur.edu.in
Source of Monetary or Material Support
All India Institute of Medical Sciences, Raipur, GE Road, Raipur, Chhattisgarh - 492099
Primary Sponsor
Name
Not applicable
Address
Not applicable
Type of Sponsor
Other [Not applicable]
Details of Secondary Sponsor
Name
Address
NIL
NIL
Countries of Recruitment
India
Sites of Study
No of Sites = 1
Name of Principal
Investigator
Name of Site
Site Address
Phone/Fax/Email
Dr Ashutosh Tripathi
All India Institute of Medical Sciences Raipur
Department of Homoeopathy, Room no-20, Fisrt Floor, AYUSH Building, AIIM, Raipur, GE Raod, Tatibandh, Raipur 492099 Raipur CHHATTISGARH
Arnica montana, Arsenicum album, Belladonna, Bryonia alba, Chamomilla, China officinalis, Digitalis purpura, Hyoscyamusnigre, Ignatiaamara, Magnespolusambu, Manganumaceticum, Menyanthes, Phosphoric acid, Pulsatilla, Rhustoxicodendron, Spigelia, Stannum metallicum
Dose: 1 (oral dose in liquid form)
Frequency: once in 45 days
Potency: 30C, 200C, 1M, LM1, LM2, LM3
Intervention: Total 2 doses of homoeopathic drug (1 dose each with a gap of 2 weeks)
17 medicines have shown alternating action (According to Dr. Hahnemann’s different writings; Post Hahnemannian Stalwarts are not included). If the prescriber of these medicines (selected on strict Homoeopathic principles) finds that no improvement follows, he should repeat the same medicine in the same potency and the improvement will soon follow
Dose: 1 (oral dose in liquid form)
Frequency: once in 45 days
Potency: 30C, 200C, 1M, LM1, LM2, LM3
Comparator Agent
Same or Higher potencies of Arnica montana, Arsenicum album, Belladonna, Bryonia alba, Chamomilla, China officinalis, Digitalis purpura, Hyoscyamusnigre, Ignatiaamara, Magnespolusambu, Manganumaceticum, Menyanthes, Phosphoric acid, Pulsatilla, Rhustoxicodendron, Spigelia, Stannum metallicum
Dose: 1 (oral dose in liquid form)
Frequency: once in 45 days
Potency: 30C, 200C, 1M, LM1, LM2, LM3
Intervention: Total 2 doses of homoeopathic drug (1 dose each with a gap of 2 weeks)
17 medicines have shown alternating action (According to Dr. Hahnemann’s different writings; Post Hahnemannian Stalwarts are not included). If the prescriber of these medicines (selected on strict Homoeopathic principles) finds that no improvement follows, he should repeat the same medicine in the same potency and the improvement will soon follow
Dose: 1 (oral dose in liquid form)
Frequency: once in 45 days
Potency: 30C, 200C, 1M, LM1, LM2, LM3
Inclusion Criteria
Age From
18.00 Year(s)
Age To
55.00 Year(s)
Gender
Both
Details
Patients prescribed medicines having alternating action (17 Medicines), in Centesimal Scale or LM Scale on Pre-Screening Visit and no improvement reported on next visit (Screening Visit).
Patients from different socio-economic status.
Patients willing to participate in the study.
Patient with chronic complaints.
ExclusionCriteria
Details
Patient suffering from any life threatening disease.
Patients having very poor general condition.
Patient not willing to participate in the study.
Patients with acute complaints.
Patients with Decimal Scale or Mother Tinctures
Patients who have received any homoeopathic medicine within last 3 months.
Method of Generating Random Sequence
Computer generated randomization
Method of Concealment
An Open list of random numbers
Blinding/Masking
Participant Blinded
Primary Outcome
Outcome
TimePoints
Improvement in in main complaint, Overall coping with the disorder and Overall well being
Day 1 (Screening visit), 15, 30 and Day 45 (End of the study visit)
Secondary Outcome
Outcome
TimePoints
superiority of Centicimal potency against LM Potency of the indicated homoeopathic medication having alternating action on non-improving chronic patients
Day 1 (Screening visit), 15, 30 and Day 45 (End of the study visit)
Target Sample Size
Total Sample Size="80" Sample Size from India="80" Final Enrollment numbers achieved (Total)= "0" Final Enrollment numbers achieved (India)="0"
Individual Participant Data (IPD) Sharing Statement
Will individual participant data (IPD) be shared publicly (including data dictionaries)?
Response - NO
Brief Summary
The study is being conducted to evaluate the efficacy of repetition of higher potency compared to a repetition of the same potency of the indicated Homoeopathic medication having alternating action on non-improving chronic patients. and to compare the superiority of Centicimal potency against LM Potency of the indicated homoeopathic medication having alternating action on non-improving chronic patients.17 medicines have shown alternating action (According to Dr. Hahnemann’s different writings; Post Hahnemannian Stalwarts are not included): Arnica montana, Arsenicum album, Belladonna, Bryonia alba, Chamomilla, China officinalis, Digitalis purpura, Hyoscyamusnigre, Ignatiaamara, Magnespolusambu, Manganumaceticum, Menyanthes, Phosphoricacid, Pulsatilla, Rhustoxicodendron, Spigelia, Stannum metallicum.If the prescriber of these medicines (selected on strict Homoeopathic principles) finds that no improvement follows, he should repeat the same medicine in the same potency and the improvement will soon follow.Every patient will be assessed periodically to follow up the reaction of the remedy through clinical assessment as well as relevant investigations. The usual follow up will be done at an interval of 2 weeks. Total 3 follow ups will be done after Screening-Visit. Oral route will be chosen for the administration of medicines. Medicines will be dispensed in liquid form using distilled water only on Day 1 and Assessment using ORIDL Scale will be done on Day 1, 15, 30 and 45.