Entrepreneurs usually work for long hours resulting in exhaustion, stress, and burnout. The prevalent symptoms of burnout include reduced levels of physical and mental energy, reduced job efficiency, and diminished productivity. Therefore, it is important to improve the health of entrepreneurs, which can be mediated effectively using gamification. Gamification has a positive relationship with improvements in health and well-being as it influences motivation, positive experiences, and satisfaction. This trial aims to study how 30-minutes of (virtual reality) game use via Kinect Azure and Oculus platforms three times per week, for three weeks, relates to differences in entrepreneur stress, burnout, subjective life quality, and downstream firm performance. Entrepreneurs over the age of 18 to 50 years will be recruited for the gamification analysis. Analysis of previous power using G*Power will be used to determine the sample size. The participants will be divided into 3 groups, wherein Group A will be assigned gamification on the Kinect platform, Group B will be assigned the Oculus Quest intervention, and Group C will be assigned a control condition. Group A and B will undergo a 30 minutes gamification module 3 days per week for 4 weeks at the NKP Salve Institute of Medical Sciences and Research Centre in Nagpur to play games on Kinect and Oculus quest respectively. The outcome measures include a five-point Likert scale for measuring entrepreneurial stress, a burnout measuring scale (BMS) for burnout, a five-point Likert scale for performance, and SF-12 for Quality of life. The questionnaires will be provided at the start of the program and the last day of each training week. Gamification techniques using Kinect Azure and Oculus Quest (i.e., virtual reality) will be integrated into entrepreneur samples to evaluate their impact on improving markers of well-being and in turn, performance. Since current strains pave the way to future accomplishment, entrepreneurs’ eudaimonic well-being might be particularly related to forward-looking challenge stressors and burnouts. The results of this study will provide an insight into how gamification could help entrepreneurs to deal with work stressors, and maintain high well-being.