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CTRI Number  CTRI/2022/07/044332 [Registered on: 26/07/2022] Trial Registered Prospectively
Last Modified On: 22/07/2022
Post Graduate Thesis  Yes 
Type of Trial  Interventional 
Type of Study   Drug
Ayurveda
Yoga & Naturopathy 
Study Design  Randomized, Parallel Group, Active Controlled Trial 
Public Title of Study   Role of relaxation and meditation in dysmenorrhea 
Scientific Title of Study   Role of Relaxation and Meditation in Primary Dysmenorrhea: A Randomized Controlled Study 
Trial Acronym   
Secondary IDs if Any  
Secondary ID  Identifier 
NIL  NIL 
 
Details of Principal Investigator or overall Trial Coordinator (multi-center study)  
Name  Dr Samidha Sharma 
Designation  Doctor 
Affiliation  PG Scholar, Department of Swasthavritta and Yoga, National Institute of Ayurveda 
Address  Room no. 201 Department of Swasthavritta and Yoga National Institute Of Ayurveda Deemed to be University Amer road Jaipur Rajasthan

Jaipur
RAJASTHAN
302002
India 
Phone  9896336779  
Fax    
Email  amodrsamidha@gmail.com  
 
Details of Contact Person
Scientific Query
 
Name  Dr Durgawati Devi 
Designation  Associate Professor 
Affiliation  National institute Of Ayurveda 
Address  National Institute Of Ayurveda Deemed to be university Jorawar singh gate Amer road Jaipur Rajasthan

Jaipur
RAJASTHAN
302002
India 
Phone  7073746600  
Fax    
Email  dvd6197@gmail.com  
 
Details of Contact Person
Public Query
 
Name  Dr Samidha Sharma 
Designation  Doctor 
Affiliation  PG Scholar, Department of Swasthavritta and Yoga, National Institute of Ayurveda 
Address  Room no. 201 Department of Swasthavritta and Yoga National Institute Of Ayurveda Deemed to be University Amer road Jaipur Rajasthan

Jaipur
RAJASTHAN
302002
India 
Phone  9896336779  
Fax    
Email  amodrsamidha@gmail.com  
 
Source of Monetary or Material Support  
National Institute Of Ayurveda 
 
Primary Sponsor  
Name  National Institute Of Ayurveda Pharmacy Department 
Address  National Institute Of Ayurveda Deemed to be university Jorawar singh gate Amer road Jaipur Rajasthan 
Type of Sponsor  Government medical college 
 
Details of Secondary Sponsor  
Name  Address 
NIL  NIL 
 
Countries of Recruitment     India  
Sites of Study  
No of Sites = 1  
Name of Principal Investigator  Name of Site  Site Address  Phone/Fax/Email 
Dr Samidha Sharma  National Institute of Ayurveda hospital  Room no. 21 Outpatient department National institute of ayurveda deemed to be university Jorawar singh gate Amer road Jaipur Rajasthan
Jaipur
RAJASTHAN 
9896336779

amodrsamidha@gmail.com 
 
Details of Ethics Committee  
No of Ethics Committees= 1  
Name of Committee  Approval Status 
Institutional ethical committee National institute of Ayurveda  Approved 
 
Regulatory Clearance Status from DCGI  
Status 
Not Applicable 
 
Health Condition / Problems Studied  
Health Type  Condition 
Patients  (1) ICD-10 Condition:N944||Primary dysmenorrhea. Ayurveda Condition: Kashtartava, (2) ICD-10 Condition:N944||Primary dysmenorrhea. Ayurveda Condition: VATAJA-ARTAVADUSHTIH,  
 
Intervention / Comparator Agent  
snoIntervention/ComparatorTypeDrug-TypeProcedure NameDetails
1Intervention ArmProcedure-Yoga practices (Procedure Reference: , Procedure details: Trial group will be supervised yoga practice at morning or evening (empty stomach or before meal) for two weeks at NIA yoga hall. After that patients will be advised to practice at home or the regular classes at NIA yoga hall. Yoga at home preference patients will be taken care of telephonically. Details of practice are as below: Nadi shodhan - 3-5 rounds which may be extended up to 10 rounds Yoga nidra - 10-15 minutes Meditation - 15- 20 minutes Patients will also be advised to )
2Comparator ArmDrugClassical(1) Medicine Name: Ashwagandha, Reference: Bhavaprakasha nighantu, Guduchyadi varga, Route: Oral, Dosage Form: Churna/ Powder, Dose: 5(g), Frequency: bd, Bhaishajya Kal: Pragbhakta, Duration: 2 Months, anupAna/sahapAna: Yes(details: -luke warm water), Additional Information: -nil
 
Inclusion Criteria  
Age From  14.00 Year(s)
Age To  30.00 Year(s)
Gender  Female 
Details  1. Patients with chief complaint of pain during menstruation for two consecutive cycles.
2. Patients willing for the trial and who will give consent.
3. Patients of age group between 14 to 30 years.
Grade 2 and 3 according to verbal multidimensional scoring system for dysmenorrhea (VMSS)
 
 
ExclusionCriteria 
Details  Any medical or gynecological history 
 
Method of Generating Random Sequence   Computer generated randomization 
Method of Concealment   Sequentially numbered, sealed, opaque envelopes 
Blinding/Masking   Not Applicable 
Primary Outcome  
Outcome  TimePoints 
Changes in menstrual distress questionnaire  2months 
 
Secondary Outcome  
Outcome  TimePoints 
Changes in the associated symptoms in primary dysmenorrhea viz nausea, vomiting, fatigue, headache, fainting, sweat, diarrhoea, constipation, vaginal discharge, breast tenderness and giddiness   2months 
 
Target Sample Size   Total Sample Size="60"
Sample Size from India="60" 
Final Enrollment numbers achieved (Total)= "Applicable only for Completed/Terminated trials"
Final Enrollment numbers achieved (India)="Applicable only for Completed/Terminated trials" 
Phase of Trial   Phase 2 
Date of First Enrollment (India)   01/08/2022 
Date of Study Completion (India) Applicable only for Completed/Terminated trials 
Date of First Enrollment (Global)  Date Missing 
Date of Study Completion (Global) Applicable only for Completed/Terminated trials 
Estimated Duration of Trial   Years="0"
Months="2"
Days="0" 
Recruitment Status of Trial (Global)   Not Applicable 
Recruitment Status of Trial (India)  Not Yet Recruiting 
Publication Details   nil 
Individual Participant Data (IPD) Sharing Statement

Will individual participant data (IPD) be shared publicly (including data dictionaries)?  

Response - NO
Brief Summary  

NEED OF STUDY:

Dysmenorrhea is commonest gynaecological disorder. The prevalence of dysmenorrhea is varying from 45% to 95% and primary dysmenorrhea is about 40-50% in reproductive age group. Nearly 40% regularly used medication and 8-15% stayed absent from work or school. Prevalence is high in adolescents about to 90%.It affects the quality of life in daily routine very significantly. Haphazard life style pattern, stress and unhealthy food habits have positive correlation with dysmenorrhea. All these are parts of modern life style, so incidence and prevalence is rising day by day. Pain bearing capacity varies from person to person but moderate and severe categories of dysmenorrhea need medication. So females generally prefer NSAIDs for pain management. These drugs do not correct the morbid reproductive physiology but subside the pain locally. Another aspect is that these drugs have their own side effects on long term use.

Yoga provides a better approach for the management of dysmenorrhea. It corrects root cause and makes the person to handle the condition by improving mental attitude. It reduces the pain sensation by progressive muscle relaxation. It also improves the mental attitude by improving sattva level and reduces stress level. Most of the women prefer non pharmacological remedies for their menstrual pain and discomfort. Yoga definitely will be helpful in this condition at physical, mental and emotional levels.

According to Acharya Charak satvavajaya and Samadhi are the key principle for the treatment of manas disorders (Ch. Su.1).Manas factor play a crucial role in causation of dysmenorrhea, so it will be definitely useful in this condition.

Aim of the study

To evaluate the effect of relaxation and meditation in primary dysmenorrhea.

Objectives of the study:

Primary: Effect of yogic relaxation and meditation on pain in primary dysmenorrhea.

Secondary:

1.     Prevalence of primary dysmenorrhea in sample population.

2.     Evaluation of yogic relaxation and meditation techniques on associated symptoms in primary dysmenorrhea.

Research Question:

Does yogic relaxation and meditation play any role in the management of primary dysmenorrhea?

Null hypothesis:

Yogic relaxation and meditation do not have any effect in the management of primary dysmenorrhea.

MATERIALS AND METHODS

Literature study: All the classical and contemporary available literature will be searched and critically evaluated. The source of literature will be printed and online both.

Study setting: Department of Swasthavritta and Yoga, Department of prasuti tantra and stri roga, National institute of Ayurveda, Jaipur

Total duration of trial: 18 months

Recruitment Period: 12 months      

Treatment Period: 2 month

Follow up: Every month during intervention and one month after completion of trial

Type of study: Intervention

Research design:

·       Type: Open Randomized Controlled clinical trial.

·       Method of randomization: By generating random number sequence using related software

·       Allocation concealment method: SNOSE

·       Number of Groups: 2

·       Type of Groups: One controlled group and one test group.

Source of Data (Population of interest): Patients with primary dysmenorrhea fulfilling the inclusion criteria.

Sample size: 60 patients will be registered and they will be divided into group A and group B. Each group will have 30 patients.

Sampling technique: Non probability method as sample frame is not available.

Inclusion criteria:

•           Patients with chief complaint of pain during menstruation for two consecutive cycles.

•           Patients willing for the trial and who will give consent.

•           Patients of age group between 14 to 30 years.

•           Grade 2 and 3 according to verbal multidimensional scoring system for dysmenorrhea (VMSS)

Exclusion criteria:

•           Any medical or gynaecological history

Discontinuation Criteria:

•           Any major illness requiring any intervention.

•           Therapy compliance less than 80 percent.

•           Person does not want to continue trial.

•           Persons not following the instructions.

•           Facing any complication during trial.

Dropouts: The reason for drop outs will be recorded and will be mentioned in dissertation.

Details of intervention:

Group A (Control): 5 gm Ashwagandha churna will be given BD with lukewarm water before meals for 2 month.

Group B (Test): This group will be supervised yoga practice at morning or evening (empty stomach or before meal) for two weeks at NIA yoga hall. After that patients will be advised to practice at home or the regular classes at NIA yoga hall. Yoga at home preference patients will be taken care of telephonically. Details of practice are as below:

Nadi shodhan  -   3-5 rounds which may be extended up to 10 rounds

Yoga nidra      -   10-15 minutes

Meditation     -   15- 20 minutes

Patients will also be advised to take satvik food for total duration of the study.

Any illness during trial: Participants will be advised to take medicine from related consultant.

Ethical aspects: Detailed information will be given to participants about therapy. Informed consent form will be given and kept for record. Privacy of the participant’s information will be maintained.

OUTCOME MEASURE:

Primary outcome: Changes in menstrual distress questionnaire

Secondary outcome: Changes in the other associated symptoms in primary dysmenorrhea.

Assessment criteria: menstrual distress questionnaire

Data will be recorded twice before and after the intervention.

Statistical Software to be used: Graph pad

Statistical test to be used: as required

Statistical analysis: at 95% confidence interval, 5% Type I error and 80% power of the study

 

 

 

 
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