Madhumeha is a clinical entity described in ayurveda as one of the types of VatajaPrameha. It is also mentioned that Madhumeha urine is sweet, slightly turbid and pale in color just like honey¹ and each and every part of the body is sweetened in this disease. Madhumeha is Santarpan ahara viharjanya vyadhi in which Kapha Dosha and Meda Dhatu Dushya is dominant. The cardinal feature of prameha has been mention “avila prabhuta mutra”. Main causes of the disease mainly excessive use of dairy products, sugar products, navdhanya, rice, sea food, excess sleep, lack of exercise. Tridosha responsible for disease as prameha which is characterized by dhushyas such as Med, rakta, vasa, lasika, mansa, rasa, oja, kleda, majja, shukra . Symptoms of prameha includes, excessive thirst, prabhutavilmutra, hast pad taldaha, gurugatrata, swedadhikya, atinidra, kshudhadhikya, daurbalya. In Margavaranjanya Madhumeha the vitiated Kapha and Meda obstructthe passage of Vata. The obstructed Vata is vitiated again and carries Ojas to Basti thus manifests Madhumeha⁷. In Madhumeha kapha is increase and mix with kleda. Kleda and meda is similer in nature. Excessive kleda mix with kapha goes to vasti and due to gurutva guna do srotoavrodh and manifest disease.

These clinical manifestations are similar to manifestations of a clinical entity named as Diabetes mellitus. Diabetes Mellitus is a group of common metabolic disorders that share the phenotype of hyperglycemia. Depending on the etiology of the Diabetes Mellitus, factors contributing to hyperglycemia include reduced insulin secretion, increased insulin resistance leading to decreased glucose utilization.