BRIEF SUMMARY ON PURPOSE –

Dermatophytosis, also known as ringworm, is a fungal infection of the skin. Dermatopytosis or tinea is predominance in about 20%-25% to all total world populations. In India, the prevalence of superficial fungal infection was 27.6%, Dermatophytosis was 75.6% and non- dermaophytosis was 24.4%. In Ayurveda, Dadrukushtha is correlated to Dermatophytosis. While thinking of the treatment, satisfactory treatment is still not available for Dermatophytosis. Modern medical science prescribed different types of treatment modalities for dermatophytosis like topical and systemic antifungal agents and use of corticosteroids which is very expensive and having side effects and also its recurrence rate is high. So, the thought of exploring a drug which is cost effective and having properties to reduce sign and symptoms of Dadru Kushtha along with least recurrence rate, triggered this clinical research. In Charak Samhita, the Kushthaghna Mahakashaya has been prescribed for the management of Kushtha and Dadrukushtha is one among the types of Kushtha.

As per Ayurveda, external application like lepa has major role in treatment of Dadru Kushtha but it has its own limitations like shorter shelf life, difficulty in handling, problem of making everyday etc. Thus, there is a need to think about its modification. So, modification of the lepa into ointment form will be performed. In the present study, an attempt was made to prepare Kushthaghna Mahakashaya Ointment for topical application.

Dadru Kushtha shows vitiation of tridoshas but according to law of predominance it shows Pitta & Kapha as major vitiation and the Rakta and Twak are considerably included in pathology as dushya. So, Jalaukaavcharan will be performed also for treatment of Dadru Kushtha.

 RESEARCH QUESTION:

Is the Kushthaghna Mahakashaya Ointment & Jalaukaavcharan effective in treatment of Dadru Kushtha?

BACKGROUND OF TRIAL: It is an interventional study.

Firstly, the Pre-clinical study will be performed to evaluate the in-vitro anti-fungal efficacy of Kushthaghna Mahakashaya and its constutuent herbs. For this ethanolic and aqueous extract of Kushthaghna Mahakashaya drugs will be taken against the fungal strains of Microsporum, Epidermophyton & Trichophyton responsible for the disease. Extraction, ointment preparation, phytochemical evaluation will be done at Research & Innovation Department, Shri Krishna AYUSH University, Kurukshetra

This is a Randomised clinical open trial, in which a minimum of 90 patients of either sex, suffering from Dadru Kushtha will be selected. The study will be conducted at Shri Krishna AYUSH University, Kurukshetra and Murari Lal Rasiwasiya Ayurvedic College Hospital, Charkhi Dadri, Haryana. Groups: 3 groups (30 patients in each group) Group A- Patients will be treated with Topical application of Kushthaghna Mahakashaya ointment sufficient for local application on affected parts of the body twice a day (morning and evening) as per the size of dadru kushtha. Group B - Patients will be treated with Jalaukaavcharan one sitting per week. Group C - Patients will be treated with Kushthaghna Mahakashaya ointment and Jalaukaavcharan both.

Period of Trial: 28 days (4 weeks).

Subjective Criteria:

Subjective parameters will be assessed before and after the treatment as per the grade score.

·         Kandu

·         Raga

·         Ruja

·         Visarpana

Objective Criteria:

ï‚· Number of Mandal

ï‚· Size of Mandal

ï‚· Number of Pidka

Laboratory Investigations

ï‚· Routine haematological investigations RBS, TLC, DLC, CT, BT, Hb%, ESR

ï‚· Urine examination - Macroscopic and Microscopic

ï‚· HIV Test, HBsAg

Finding – There will be a significant effect of Kushthaghna Mahakashaya ointment and Jalaukaavcharan in the management of Dadru Kushtha w.s.r.to Dermatophytosis.