1. What data in particular will be shared?
   Response - All of the individual participant data collected during the trial, after de-identification.
   


2. What additional supporting information will be shared?
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   Response - Clinical Study Report
   
   
3. Who will be able to view these files?
   Response - Researchers who provide a methodologically sound proposal.
   


4. For what types of analyses will this data be available?
   Response - To achieve aims in the approved proposal.
   


5. By what mechanism will data be made available?
   Response (Others) - 


6. For how long will this data be available start date provided 23-10-2021 and end date provided 23-10-2026?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

Surgical pain is a universal phenomenon affecting all patients perioperatively. Apart from the agonizing sensory experience associated with it, acute pain has several deleterious effects on the physiology and the psyche of the sufferer(3).An anticipation of these effects combined with a humanitarian urge to relieve pain, play a pivotal role in provision and optimization of postoperative analgesia.

Laparoscopic cholecystectomy is a minimally invasive procedure which is increasingly performed as a day care procedure.

Though minimally invasive, pain experienced following laparoscopic cholecystectomy in the immediate postoperative period may vary from moderate to severe in intensity.

Pain after laparoscopic cholecystectomy can be divided into three compartments; visceral, parietal and referred shoulder pain.

The main sources of pain include pain from incision sites(50-70%),pnemoperitoneum(20-30%),and post cholecystectomy wound(10-20%) within the liver causing visceral pain. Postoperatively common location of the pain is right upper quadrant and port sites.

The main objective of treating the post-operative pain is to eradicate or, to minimize the pain and to speed up the healing process without any side effects.

As a part of multi-modal analgesia, various approaches are employed for achieving safe and effective post operative analgesia. Clinical application of conventional perioperative analgesic modalities(eg.opoids,epidural analgesia)was limited because of their own drawbacks.

Transversusabdominis plane block (TAP) that delivers local anaesthetic into transversusabdominis plane has been shown to reduce perioperativeopoid use in elective abdominal surgery,including open appendicectomy,laparoscopic cholecystectomies,caesarean section and laparotomies.

The use of point of care ultrasonography in abdominal blocks increases the success rate and safety of the block .A variant of TAP block is (SCTAP)block where the local anesthetic is deposited between the transverse abdominis plane inferior and parallel to the costal margin. The  Subcostal  transverses abdominis plane block provides adequate analgesia for supraumbilical surgeries because of its greater cranial spread(T6-T10).

MULTIMODAL ANALGESIA-Is defined as the use of more than one pharmacological class of analgesic medication targeting different receptors along the pain pathway with the goal of improving analgesia while reducing individual side effects.(1)

Multi-modal analgesia in the peri-operative period eliminates over reliance on opoids for pain control and to reduce opoid related side effects.

Preemptive multi-modal analgesia,combining non-opoid analgesics,Paracetamol,non steroidalani-inflammatory drugs or coxib and local anaesthesia has a long history. Local anesthesia improves postoperative pain and facilitates discharge on the day of surgery(4).

Thus the aim of the present study is to summarize the available best evidence and well established practice for perioperative analgesia in elective laparoscopic cholecystectomy.