Arthritic pain is common and is associated with worst functional outcome and poorer quality of life. Most commonly used drug in clinical practice is Tramadol and Diclofenac. Routinely NSAIDS are given along with PPI.In addition to anti-secretory effects, however, PPIs have shown anti-inflammatory effects . But the role of PPIs as anti-inflammatory agents in addition to acid lowering property  in osteoartharitis and cost effectiveness remains to be explored. In developing countries it is very important to assess what drugs may decrease the subsequent use of medical care resources considering their adverse events that are known to have a significant increase in medical care costs of patients with osteoarthritis..Keeping the above limitations in mind we have designed a study to evaluate cost effectiveness and safety between two most commonly used drugs.

The primary outcome measures will be by KOOS questionnaire:The Knee injury and Osteoarthritis Outcome Score,  and pain assessment by Visual analouge scale at 2 and 4 wks.Cost  effectiveness ratio for different groups will be  calculated by dividing the cost of treatment by its clinical outcome to yield the ratio in terms of rupees.  Adverse events spontaneously reported by patients and adverse events observed by the investigator will be recorded at each visit.