1. What data in particular will be shared?
   Response - Individual participant data that underlie the results reported in this article, after de-identification (text, tables, figures, and appendices).
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   Response -  Statistical Analysis Plan
   Response - Informed Consent Form
   Response - Clinical Study Report
   
   
3. Who will be able to view these files?
   Response - Researchers whose proposed use of the data has been approved by an independent review committee identified for this purpose.
   


4. For what types of analyses will this data be available?
   Response - Any purpose.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [bhavish.s.reddy@protonmail.com].
   


6. For how long will this data be available start date provided 01-10-2021 and end date provided 01-01-2023?
   Response - Immediately following publication. No end date.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - nil

           Endotracheal intubation is a commonly used mode of securing and isolating the airway in patients receiving general anaesthesia. This is well tolerated when the patient is under adequate anaesthetic depth. However during emergence from general anaesthesia, an extubation stress response involving cough and adverse hemodynamic changes like tachycardia and hypertension has been identified and studied by various authors. ^(1-5) It is a significant and alarming event to the patient undergoing extubation and may cause various distressing complications like surgical site re-bleeding, laryngospasm, hypertension, myocardial ischemia, oxygen desaturation, and violent behavior leading to injury to the patient, healthcare personnel and support staff. ^(1,2) It is desirable to avoid these unfavourable changes in patients during the time of extubation after surgery.

Many pharmacologic agents like lignocaine, opioids, calcium channel blockers, esmolol, magnesium sulphate, propofol, etc. have been shown to attenuate these responses. ^(2,3,6) Dexmedetomidine is one such drug. It is an alpha-2 adrenergic receptor agonist. It finds use in the intensive care setting for sedation of intubated patients and also in non-intubated patients for sedation in the perioperative period without depressing the respiratory drive. ⁽²⁾ It has been used in various doses ranging from 0.5mcg/kg to 1mcg/kg; with all doses providing adequate sedation but higher doses increasing the risk of adverse hemodynamic outcomes. ⁽⁴⁾  It has also been found that a single bolus administration of dexmedetomidine is associated with a lower incidence of emergence delirium and pain scores as compared to a continuous infusion. ⁽⁵⁾ Thus, a single bolus dose of dexmedetomidine is an easy and straightforward technique to reduce extubation stress response.

            We intend to study the effect of a single bolus dose of dexmedetomidine on the prevention of cough response at the time of extubation. We also intend to study hemodynamic changes, adverse events and post-operative sedation over the course of emergence from general anaesthesia.