1. What data in particular will be shared?
   Response - All of the individual participant data collected during the trial, after de-identification.
   


2. What additional supporting information will be shared?
   Response -  Study Protocol
   
   
3. Who will be able to view these files?
   Response - Anyone
   


4. For what types of analyses will this data be available?
   Response - Any purpose.
   


5. By what mechanism will data be made available?
   Response - Proposals should be directed to [drvenkat94@gmail.com].
   


6. For how long will this data be available start date provided 21-09-2021 and end date provided 20-09-2026?
   Response - Beginning 3 months and ending 5 years following article publication.
   


7. Any URL or additional information regarding plan/policy for sharing IPD? 
   Additional Information - NIL

     After obtaining the scientific committee and ethical committee clearance, informed consent written in their own language will be obtained from all the patients Included in the study. Study will be done on patients who are posted for elective surgery for spine fixation under prone positioning in SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTER, KATANKULLATHUR. Study will be   performed as a prospective randomized single-blinded control study in patients undergoing elective Spine instrumentation surgeries in prone position under general anaesthesia.. Patients will be randomized into three groups by computer generated random numbers and kept in a sealed, opaque envelope.

Group A: No PEEP

Group B: PEEP of 5.

Group C: PEEP of 10.

General anaesthesia will be standardized in all the groups. The patients will be premedicated with alprazolam on the night and two hours before surgery. The patients will be monitored with pulse oxymeter, NIBP, ECG and capnography. Glycopyraollate 0.2mg + Ondansetron 4mg IV will be administered. Morphine 0.15mg/kg will be used as the intraoperative analgesic. Propofol 2 mg/kg is the induction agent and vecuronium 0.1mg/kg is used for intubation. Anaesthesia will be maintained with O2: air with sevoflurane. Patient will be ventilated with Pressure Controlled Ventilation (PCV) to achieve a tidal volume of 7 ml/kg. Respiratory rate will be  kept at 12/min. ETCO2 between 36 and 40. The amount of PEEP will be kept according to the group allotted. Three different timelines will be used to monitor the arterial po2, Peak pressure, plateau pressure and mean pressure, dynamic compliance: before induction (T1), 30 min after prone positioning (T2), and arterial po2 will be seen 30 mins after  extubation. Arterial line will be inserted after shifting the patient to OT. ABG will be taken at the three time lines to look for pH, PO2, and PCO2. The Peak pressure, plateau pressure and mean pressure, dynamic compliance will be measured every 15 min intraoperatively. The haemodynamic parameters like HR and MAP will also be measured every 15 min intraoperatively. The total intraoperative blood loss will be calculated at the end of surgery in all three groups. If MAP reduces by more than 20% from baseline, it will be considered as hypotension. Hypotension will be treated initially with crystalloids and ephedrine in increments of 6mg if necessary.